卡托普利治疗有合并症的老年原发性高血压的临床疗效及安全性评价

Clinical efficacy and safety evaluation of Captopril in treatment of elderly patients with primary hypertension

目的探讨卡托普利治疗有合并症的老年原发性高血压的临床疗效及安全性。方法抽取2014年2月—2015年11月接收的102例老年原发性高血压患者,根据入院顺序分组,各51例。常规组采用阿替洛尔治疗,研究组在常规组用药基础上加用卡托普利。对比两组临床疗效、不良反应发生率及治疗前后甘油三酯、总胆固醇、空腹血糖、心率、舒张压及收缩压水平变化情况。结果研究组治疗总有效率为96.08%,常规组为82.35%,组间比较差异有统计学意义(P<0.05);治疗前两组甘油三酯、总胆固醇、空腹血糖、心率、舒张压及收缩压水平对比差异无统计学意义(P>0.05),经治疗研究组各项指标水平显著优于常规组,差异有统计学意义(P<0.05);两组治疗过程中均未发生明显不良反应。结论在常规用药基础上加用卡托普利治疗伴有并发症的老年原发性高血压患者效果显著,可有效改善其血压、血糖等相关指标水平,提高治疗效果,且不会增加不良反应发生率,具有一定安全性。

Objective To investigate the clinical efficacy and safety of Captopril in the treatment of elderly patients with essential hypertension. Methods Totally 102 cases of elderly patients with essential hypertension received in our hospi- tal from November -2015 to February 2014 were grouped according to the order of admission, with 51 cases in each group. The conventional group received atenolol treatment; study group was treated with captopril based on the treatment of conventional group. The clinical effect, incidence of adverse reactions and the changes of triglyeeride, total cholester- ol, fasting blood glucose, heart rate, diastolic blood pressure and systolic blood pressure were compared between the two groups. Results The total effective rate was 96. 08% in the study group and 82. 35% in the conventional group, and the difference was statistically significant （ P 〈 0. 05 ） ; There was no significant difference in the level of triglyceride, to- tal cholesterol, fasting blood glucose, heart rate, diastolic blood pressure and systolic blood pressure between the two groups （ P 〉 O. 05 ）. After treatment, the indexes of the study group were significantly higher than that of the convention- al group, the difference was statistically significant （ P 〈 0. 05 ） ; There were no obvious adverse reactions in the two groups. Conclusion The effect of eaptopril based on the conventional treatment in elderly patients with complica- tions of high blood pressure is significant. It can effectively improve the level of relevant indicators of blood pres- sure, blood sugar, and improve the therapeutic effect. And it can not increase the incidence of adverse reactions with a certain security.