体素内不相干运动双指数模型的技术现况

The technology progression of intravoxel incoherent motion on biexponential model

体素内不相干运动(intravoxel incoherent motion,IVIM)通过多b值扩散加权成像,可无创性地区分组织中的单纯水分子扩散(D)与灌注相关扩散(D*、f),进而对它们进行量化分析。IVIM双指数模型已获得了广泛的关注,并应用于全身多脏器及其相关疾病的诊断及鉴别诊断、疗效评估或预测、病变分期或分级、与其他成像方式相结合等方面的研究中。本文对IVIM双指数模型的扫描方式及其影响因素、b值选取、参数重复性及其意义、灌注参数的准确性等成像技术方面的研究现况和进展予以评述。

Intravoxel incoherent motion （IVIM） is a quantitative method that can be used to noninvasively distinguish tissue diffusivity from perfusion related-diffusion by multiple b values sampling on diffusion-weighted imaging. IVIM biexponential model has not only attracted broad attention, but also been applied in the researches of disease diagnosis and differentiation, evaluation or prediction of therapeutic effect, lesion staging or grading and combination of other imaging patterns. The current research situations and progresses on technology, such as scanning methods, the choice orb value, the repeatability and significance of parameters, and the accuracy of perfusion-related parameters, are mainly discussed in this article.