磁共振成像技术在特发性震颤中的研究进展

Progresses in magnetic resonance imaging of essential tremor

特发性震颤(essential tremor,ET)是最常见的中枢源性运动障碍疾病之一,其病因、发病机制以及病理生理改变目前尚不清楚。组织病理学检查是揭示其病理生理改变最有效的方法,然而特发性震颤患者尸检率低,以磁共振成像(magnetic resonance imaging,MRI)为代表的无创检查方法已成为研究其病理生理改变的主要手段。本文将从磁共振成像新技术,包括基于体素的形态学分析(voxel-based morphometry,VBM)、扩散张量成像(diffusion tensor imaging,DTI)以及静息态功能磁共振成像(resting-state functional MRI,rs-f MRI)3个方面综述特发性震颤的研究进展。

Essential tremor （ET） is one of the most common movement disorder origining from the central nervous system in adults. The pathophysiology of ET remains unclear. Histopathological examination is the most effective method to ascertain the pathophysiology changes. However, the autopsy rate is very low. Magnetic resonance imaging （MRI） provides reliable evidence for the functionalpathological mechanism of ET. The latest progresses in the field of voxel-based morphornetry （VBM）, diffusion tensor imaging （DTI） and resting-state functional magnetic resonance imaging （rs-tMRI） of ET were reviewed in this paper.