炎症相关因子基因多态性与弥漫大B细胞淋巴瘤的易感性研究

Gene Polymorphism of Inflammation-related Cytokines Correlates with the Susceptibility to DLBCL

目的:探讨甘肃汉族人群中炎症相关因子基因多态性与弥漫大B淋巴瘤(diffuse large B-cell lymphoma,DLBCL)发病率的相关性。方法:运用高分辨率溶解曲线(high-resolution melting,HRM)方法检测炎症因子基因多态性。结果:IL-1RA的rs4251961位点CC纯合子基因型携带者与患DLBCL风险有关(以TT为参照,CC基因型的OR为0.83,95%CI=0.697-0.997,P<0.05),但与T等位基因相比,C等位基因与DLBCL风险升高显著相关(OR=8.83,95%CI=1.909-40.813,P<0.01)。结论:IL-1RA的rs4251961位点的次等位基因C与DLBCL的易患性显著相关。

Objective： To investigate the relationship of gene polymorphisms of inflammattion related cytokines with incidence of diffuse large B-cell lymphoma（DLBCL） in Gansu Han population. Methods： The gene polymorphism of inflammation-related cytokines were detected by high-resolution melting （HRM） curve. Results： The homozygous CC genotype carrying IL-1RA rs4251961 gene locus was related with the risk of DLBCL in comparison with homozygous TT, the OR was 0. 83 of homozygous CC, 95 % CI = 0. 697 - 0. 997, P 〈 0. 05 ）, while the C allele of IL-1RA rs4251961 gene locus significantly correlated with the high incidence of diffuse large B-cell lymphoma compared with T allele（ OR =8.83, 95% CI = 1.909 -40. 813,P 〈 0.01 ）. Conclusion： The minor allele C of IL-1RA rs4251961 gene locus significantly relates with the susceptibility to DLBCL.