CCR7在多发性骨髓瘤中的表达及其与髓外病变的关系

Expression of CC-chemokine Receptor 7 in Patiens with Multiple Myeloma and Its Relationship with Extramedullary Disease

目的:检测趋化因子受体-7(CC-chemokine receptor 7,CCR7)在多发性骨髓瘤中的表达水平,探讨其与疾病特征的关系。方法:采用流式细胞术测定53例新诊断的多发性骨髓瘤患者的骨髓浆细胞CCR7的表达水平,分析其与年龄、性别、M蛋白、外周血细胞计数、血生化指标、骨髓浆细胞比例、免疫表型特点、溶骨改变、髓外病变等疾病特征的关系。结果:53例多发性骨髓瘤患者中CCR7阳性者24例,阳性率为45.28%,CCR7阳性组髓外病变发生率高于CCR7阴性组(29.17%vs 3.45%)(P<0.05)。结论:CCR7在多发性骨髓瘤中表达较高,其高表达与髓外病变发生相关,CCR7可能是预测多发性骨髓瘤发生髓外病变的重要指标。

Objective： To investigate the expression of CC-chemokine receptor 7 （CCR7） in patients with multiple myeloma（MM） and its correlation with clinical features of MM. Methods： The level of CCR7 expression in bone marrow samples from 53 newly diagnosed MM patients was detected by flow cytometry（FCM）. Statistical methods were used to analyze the correlation between CCR7 expression and clinical features, such as sex, age, M protein, peripheral blood cell count, biochemical indicators, plasma cell ratio of bone marrow, immunophenotype, osteopathy and extramedullary disease. Results： The plasma cells in 24 out of 53 cases（45. 28% ） expressed CCR7. The rate of extramedullary disease in CCR7 positive group was significantly higher than that in CCR7 negative group （29. 17% vs 3.45 % ） （ P 〈 0.05 ）. Conclusion： The expression of CCR7 in patients with MM is high, moreover this high expression correlates with extramedullary disease, thus CCR7 can be used as an effective indicator for prediction of extramedullary disease.