音乐刺激孕鼠对子代鼠大脑功能影响的系统评价

Evaluation of the effect of music given to pregnant rats on the development of brain functions in offspring rats

目的系统评价音乐刺激孕鼠对子代鼠大脑功能的影响效果,为促进实验动物的福利以及音乐胎教的应用发展提供科学依据。方法计算机检索Pubmed、Web of Science、Cochrane Library、万方、维普、中国知网和中国生物医学文献数据库,全面收集有关音乐刺激孕鼠对子代鼠大脑功能影响效果的研究文献,检索时限为建库至2016年4月2日。按照纳入与排除标准选择文献、评价文献质量和提取数据,并对数据进行定性描述。结果共纳入7篇实验研究,4篇中文,3篇英文。研究对象均为大鼠,其中5项研究采用Wistar大鼠,2项研究采用SD大鼠。音乐材料涉及舒适音乐、古典音乐、小提琴协奏曲(梁祝),干预周期为妊娠期至分娩期前后不等。研究结果显示:孕期音乐刺激在一定程度上能促进子代大鼠的大脑神经发生,提高空间记忆能力,但对某些功能性受体的表达影响不显著。结论适宜的音乐可以促进子代大鼠大脑功能的发展。

Objectives To systematically evaluate the effect of music given to pregnant rats on the development of brain functions in the offspring rats and to provide scientific evidence for the application of antenatal musical training and the promotion of welfare for laboratory animals. Methods We comprehensively retrieved and collected the research litera- tures related to the effect of music on brain function development in offsprings of the pregnant rats from Pubmed, Web of Science, Cochrane Library, Wanfang, Weipu, CNKI and CBMdisc. The retrieval time was set from the foundation date of databases to 2 April, 2016. We selected literatures according to the inclusion and exclusion criteria, evaluated their utili- ties, then extracted and qualitatively described the data. Results Seven experimental studies were selected in this study including 4 published in Chinese and 3 in English. The object laboratory animals of those studies were Wistar or SD rats. Music materials involved comfort music, classic music, violin concerto（ Liangzhu/The butterfly lovers）. Intervention were given to the pregnant rats roundly from the gestation until parturition. These results showed that, to some extent, music stimulations during gestation may promote the development of brain function and improve spatial memory of the offspring rats. However,expressions of some functional receptors were not significantly altered. Conclusions Appropriate music pro- vided to the pregnant rats promote the development of brain functions in their offspring.