老年艾滋病抗病毒治疗临床疗效观察

Clinical observation of antiviral therapy in elderly AIDs patients

目的探讨老年艾滋病抗病毒治疗的临床疗效及特点。方法选取该院2013年1月至2015年6月自愿接受国家免费抗病毒治疗的艾滋病患者108例,其中老年艾滋病组(老年组)54例,非老年艾滋病组(非老年组)54例,对所有入组患者实施1年的抗病毒临床疗效监测。观察两组治疗前后病毒抑制率、CD4^+T淋巴细胞、血常规及药物不良反应。结果抗病毒治疗后,两组患者病毒抑制率比较,差异无统计学意义(P>0.05);治疗后非老年组CD4^+T淋巴细胞较老年组明显升高,差异有统计学意义(P<0.05);治疗后老年组免疫重建不良发生率较非老年组高,差异有统计学意义(P<0.05);老年组药物不良反应发生情况较非老年组高,其中老年组贫血与消化道反应的发生率较非老年组高,差异有统计学意义(P<0.05)。结论老年艾滋病抗病毒治疗其病毒抑制率与非老年组比较无差异,但其免疫重建功能较非老年组高,不良反应相对多。

Objective To study the curative effect and clinical characteristics of antiviral therapy in elderly AIDs pa- tients. Methods A total of 108 AIDs patients,who voluntarily accepted national free antiviral therapy from January 2013 to June 2015 in the hospital ,were selected, including 54 cases of elderly AIDs patients （the elderly group ） and 54 cases of non elderly AIDs patients （the non elderly group）. The clinical efficacy of all the involved patients was monitored after 1-year antiviral thera- py,and the virus inhibition rate,CD4＋ T cells, blood routine and adverse drug reaction in the two groups were observed before and after treatment. Results After antiviral therapy,the virus inhibition rate between the two groups had no statistical signifi- cance（P〉0.O5 ） ;the amount of CD4＋ T cells in the non elderly group was higher than that in the elderly group after treatment ,with statistically significant difference （P〈O.05） ; the adverse reaction rate of immune reconstruction after treatment in the elderly group was higher than that in the non elderly group,with statistically significant difference （P〈O.05） ; the incidence of adverse drug reac- tion in the elderly group was higher than that in the non elderly group ,while the difference on incidence rates of anemia and gas trointestinal reaction between the two groups had statistical significance （P〈0.05）. Conclusion There is no difference on virus inhibition rate between the two groups, hut the immune reconstruction function in the elderly group is higher than that in the non elderly group, and the adverse reaction is relatively more in the elderly group.