血白细胞计数和C-反应蛋白与晚期先兆流产保胎结局的关系

Analysis of the relationship between the outcomes of protecting fetus from late threatened abortion and white blood cell count,C-reactive protein

目的研究血白细胞计数和C-反应蛋白与晚期先兆流产保胎结局的关系。方法选择2013年1月至2015年12月217例有晚期先兆流产症状的孕妇,其中保胎成功171例,保胎成功率为78.8%;难免流产46例,难免流产率为21.2%。所有孕妇住院期间接受同样的治疗,分析比较两组血白细胞计数和C-反应蛋白值。结果难免流产组两项指标都高于成功保胎组,差异有统计学意义(P<0.05);随着血白细胞计数和C-反应蛋白值的上升,保胎成功率下降,难免流产率上升,拟合曲线方程R2值均>0.9,差异有统计学意义;相关性分析研究显示,保胎成功与血白细胞计数及C-反应蛋白值呈负相关,难免流产与血白细胞计数及C-反应蛋白值呈正相关;据ROC曲线下面积分析血白细胞计数和C-反应蛋白对预测保胎结局有统计学意义(P<0.05)。结论 C-反应蛋白和血白细胞计数对晚期先兆流产的保胎结局具有中等预测价值,其中C-反应蛋白预测价值更大。

Objective To study the relationship between white blood cell count（WBC）, C-reactive protein（CRP） and the outcomes of protecting fetus from late threatened abortion. Methods Two hundred and seventeen pregnant women with advanced threatened abortion from January 2013 to December 2015 were selected. One hundred and Seventy-one pregnant women successfully protected the fetus, the success rate was 78.8% ; inevitable abortion in 46 cases, the inevitable abortion rate was 21.2%. The WBC and CRP were analyzed and compared between the two groups. Results The two indexes of inevitable abortion group were higher than those of successfully protected the fetus group, the differences were significant （ P 〈 0. 05）. Correlation analysis showed that successful protection the fetus was negatively correlated with WBC and CRP,and there was positive correlation of the inevitable abortion with WBC and CRP. According to the area under the ROC curve, WBC and CRP had significance in the predictionof the outcomes of protecting fetus （P 〈 0. 05 ）. Conclusion CRP and WBC have moderate predictive value for convalescentoutcomes in advanced threatened abortion, the value of C-reactive protein is more predictive.