白三烯B4与脑动脉硬化所致进展性缺血性脑卒中的相关性分析

Association between leukotriene b4 and progressive ischemic stroke caused by cerebral arteriosclerosis

目的探究白三烯B4在脑动脉硬化所致进展性缺血性脑卒中发病中的影响作用,对两者相关性进行研究。方法选取37例脑动脉硬化所致进展性缺血性脑卒中患者为观察组,37例非进展性的缺血性脑卒中患者为对照组。比较两组患者血压、血糖、血脂指标、白三烯指标、动脉粥样硬化、吸烟、饮酒、颈动脉狭窄等指标,并进行多因素logistic回归分析。结果两组患者舒张压、血糖、总胆固醇、甘油三酯、低密度脂蛋白、血清白三烯B4、吸烟史、喝酒史、动脉粥样硬化比较,差异均有统计学意义(t分别=2.23、2.22、8.18、14.23、4.16、2.44、2.44、2.35;χ~2=4.16,P均<0.05)。多因素logistic回归分析显示高血压、高水平白三烯B4、高血糖、动脉粥样硬化、颈动脉狭窄是脑动脉硬化所致进展性缺血性脑卒中的危险因素(OR分别=1.93、2.72、3.01、3.52、3.01,P均<0.05)。结论高水平白三烯B4是脑动脉硬化所致进展性缺血性脑卒中的危险因素。

Objective To investigate the effect of leukotriene B4 on the progression of ischemie stroke induced by cerebral arteriosclerosis and explore the correlation between them. Methods A total of 37 patients with progressive isehemie stroke caused by cerebral arteriosclerosis were selected as the observation group and 37 patients with non - progressive ischemie stroke as the control group. The blood pressure,blood glucose,lipid index,leukotriene index,the number of atherosclerosis,smoking,alcohol consumption and carotid artery stenosis were compared between the two groups. Multivariate logistic regression analysis was performed. Results There were significant differences in diastolic blood pressure,blood glucose,TC,TG,LDL, B4,smoking history, drinking history and atherosclerosis rate between the two groups （t=2.23,2.22,8.18,14.23,4.16,2.44,2.44,2.35,x^2= 4.16,P〈0.05）. Multivariate logistic regression analysis showed that hypertension,leukotriene B4,hyperglycemia,atherosclerosis and carotid artery stenosis were risk factors for progressive ischemic stroke caused by cerebral arteriosclerosis （OR=1.93,2.72,3.01,3.52,3.01,P〈0.05）. Conclusion High level of leukotriene B4 is a risk factor for progression of ischemic stroke caused by cerebral arteriosclerosis.