摘要
研究桦木酸对胃黏膜的保护作用。采用无水乙醇灌胃法建立大鼠胃黏膜损伤模型,以溃疡指数和溃疡抑制率表示大鼠胃黏膜损伤程度。结果表明,桦木酸能显著降低胃黏膜损伤模型的溃疡指数,提高其溃疡抑制率和胃内容物pH值(P<0.01)。说明桦木酸对大鼠乙醇胃黏膜损伤具有保护作用,该作用可能与其减少胃酸分泌以及增强组织自身生长和修复能力等有关。
Objective： In order to investigate the protective effect of betulinie acid on gastric mucosa, Methods： Acute gastriculcer was induced in rats with absolute ethyl alcohol.The uh＇er index and inhabitation rate of ulcer were used to evaluate the extentof the gastric mucosa injury. Results： Betulinic acid could significantly reducedethanol-induced ulcer index, enhance theinhabitation rate of ulcer and pH value of gastric contents. Conlusion： Betulinic acid has protective effects on ethanol-inducedgastric mucosa injury in rats,which may b- related to inhibiting gastric acid secretion and enhancing tissue regeneration capacity.
出处
《中兽医医药杂志》
2017年第2期14-16,共3页
Journal of Traditional Chinese Veterinary Medicine
基金
湖南省科技计划项目(2015NK3008)
湖南省自然科学基金项目(2015JJ2077)
国家级大学生创新创业训练计划项目[(G)SCX1609]
湖南省大学生研究性学习和创新性实验计划项目(SCX1609)
关键词
桦木酸
胃黏膜
乙醇
betulinic acid
gastric mucosa
ethanol
