开放性眼外伤合并海水浸泡后兔眼球内容物电解质浓度及病理变化

Changes in electrolyte concentration and pathology ocular trauma coupled with seawater immersion of the eyeball content in rabbits following open ocular trauma coupled with seawater immersion

目的 对兔开放性眼外伤合并海水浸泡伤后晶状体和玻璃体中Ca2＋、Na＋ 、K＋的浓度进行测定，并观察其眼球结构形态学变化。方法 在伤后的不同时间点采用光谱仪测定晶状体和玻璃体内Ca2＋、Na＋ 、K＋的含量，同时观察眼球晶状体的变化。结果 海水浸泡时Ca2＋、Na＋浓度逐渐升高，晶状体K＋浓度不断下降，玻璃体K＋持续升高，时间越久，变化越明显。浸泡30 min组持续观察7 d，Ca2＋、Na＋ 、K＋含量略高，14 d时完全恢复正常。浸泡30 min组晶状体小部分混浊，浸泡2 h以上组晶状体大部混浊。结论 晶状体和玻璃体内电解质Ca2＋、Na＋ 、K＋浓度的变化与眼球损伤有着密切关系，超过0.5 h浸泡的眼球恢复存在极大困难。

Objective To observe changes in electrolyte concentration and pathology of the eyeball content in rabbits following open ocular trauma coupled with seawater immersion.Methods Ca2＋ , Na＋ , K＋ levels in the lens and vitreous body were determined at the different time points with spectrometry following open ocular trauma coupled with seawater immersion. Changes in the lens were also observed.Results Following seawater immersion, Ca2＋ , Na＋ concentrations of the lens and vitreous body gradually increased, while K＋ concentration of the lens continuously decreased and that of vitreous body continuously elevated, and those changes became increasingly obvious with the extension of time. One-week continuous observation after half-hour immersion indicated that Ca2＋ , Na＋ , K＋ levels were slightly higher, but returned to normal after 2 weeks. A small part of the lens became cloudy after 30-minute immersion, and most part of the lens was cloudy after 2-hour immersion.Conclusions Changes in the levels of Ca2＋ , Na＋ and K＋ in the lens and vitreous body were closely associated with ocular lesion. It was difficult for the eye ball to recover after over half an hour seawater immersion.