非甾体类抗炎药的毛细管电色谱分析研究

Investigation of capillary electrochromatography for non-steroidal anti-infl ammatory drugs

论文应用氰基键合毛细管开管柱,建立了非甾体类抗炎药(舒林酸、芬布芬、布洛芬、萘普生、酮洛芬、氟比洛芬和双氯芬酸钠)的开管毛细管电色谱分析模式。在最优分离条件下,七种非甾体类抗炎药在18分钟内实现良好分离,其线性范围均为1.5×10^(-5)mol/L-4.0×10^(-4)mol/L,检测限在3.5×10^(-6)mol/L-1.0×10^(-5)mol/L之间。应用于猪肝样品分析,平均回收率在85.0%-92.6%之间。该方法为非甾体类抗炎药的分离测定提供了新的技术。

Capillary Electrochromagraphy with a cyanophoric-based open tubular column, was employed for the analysis of seven non-steroidal anti-inflammatory drugs （sulindac, fenbufen, ibuprofen, naproxen, ketoprofen, flubiprofen, Diclofenac sodium）. Under optimum conditions, seven non-steroidal anti-inflammatory drugs achieved satisfactory separation in 18 rain. the linear calibration ranges were between 1.5×10-5 mol/L - 4.0×10-4 mol/L and the LODs were between 3.5 mol/L×10-6 - 1.0×10-5 mol/L, respectively. The method was applied to the determination of non-steroidal anti-inflammatory drugs in pig liver. Recoveries of seven non-steroidal anti-inflammatory drugs in Pigs Liver were in the range of 85.0% - 92.6%. it may provide a potential way for the analysis of non-steroidal anti-inflammatory drugs.