生长抑素联合介入性动脉灌注化疗治疗恶性肠梗阻临床观察

Clinical observation of somatostatin combined with transcatheter arterial infusion chemotherapy in the treatment of malignant intestinal obstruction

目的 观察生长抑素联合介入性动脉灌注化疗在恶性肠梗阻治疗中的效果,以探索最有效的非手术治疗方法。方法以2013年1月~2015年6月来丽水市中心医院治疗符合纳入条件的恶性肠梗阻患者60例为研究对象。随机分为4组;常规组15例,生长抑制组15例,低剂量动脉灌注化疗组15例以及生长抑素加低剂量动脉灌注化疗组15例。比较4组患者临床症状缓解时间,临床症状缓解的持续时间以及生存时间的差异。结果 研究表明含生长抑素组的胃肠减压量和症状缓解时间都明显优于常规组。尤其是症状缓解时间上要明显快于常规组和动脉灌注化疗组（P〈0.05）;动脉灌注化疗组和生长抑素＋动脉动脉灌注化疗组在生存时间和症状缓解的持续时间上,都明显优于常规组和生长抑素组（P〈0.05）。结论 在恶性肠梗阻的治疗中生长抑素有利减少胃肠减压量,快速缓解恶性肠梗阻的临床症状。而腹腔动脉灌注化疗有助于提高恶性梗阻的症状缓解的维持时间和延长患者生存期。联合生长抑素和腹腔动脉灌注化疗有利于短时间缓解症状的同时延长症状缓解时间间期,提高患者的生存时间。

Objective To observe the effect of somatostatin combined with transcatheter arterial infusion chemotherapy in the treatment of malignant intestinal obstruction. Methods 60 patients with malignant intestinal obstruction were enrolled in our hospital from January 2013 to June 015. The rats were randomly divided into 4 groups： the conventional group （ n, = 15 ） , the growth inhibition group （ n, = 15 ） , the low dose intra-arterial nfusion chemotherapy group （ n, = 15 ） and somatostatin plus low-dose intra-arterial infusion chemotherapy group （n = 15 ） . The clinical symptom emission time, duration of clinical symptom remission and survival time were compared between the four groups. Results The study showed that omatostatin group of gastrointestinal decompression and symptom remission time were significantly better than the conventional group. Especially the ymptom remission time is significantly faster than the conventional group and chemotherapy group （P 〈 0. 0 5 ） ; the duration of chemotherapy group and omatostatin ＋ artery perfusion chemotherapy group in survival time and relieve symptoms, were significantly better than the conventional group and omatostatin group （P 〈 0. 05 ）. Conclusion Somatostatin is beneficial to reduce the amount of gastrointestinal decompression in the treatment of malignant intestinal obstruction. Celiac artery infusion chemotherapy can help to improve the maintenance time and prolong the survival time of patients with malignant obstruction. The combination of somatostatin and celiac artery infusion chemotherapy is beneficial to relieve the symptoms and prolong the me interval, and improve the survival time of patients.