双歧三联活菌联合锌剂对小儿腹泻患者血清hs-CRP水平及临床疗效的影响

Effect of bifidobacteria combined with zinc on serum CRP level and clinical efficacy in children with diarrhea

目的 探讨采用双歧三联活菌与锌剂的联合应用对小儿腹泻患者的血清超敏C反应蛋白水平及临床疗效影响研究。方法 选取2013年6月~2016年6月期间嘉兴市第一医院收治的小儿腹泻患者100例作受试者,按随机数字表法分为2组,对照组50例患者进行防脱水、锌剂补充等一般常规治疗,治疗组50例在对照组基础上联合双歧三联活菌对腹泻小儿患者进行控制。观察和比较2组患者的临床疗效,腹泻各项临床症状消失时间及血清超敏C反应蛋白（hs-CRP）、白细胞介素-10（IL-10）、白细胞介素-6（IL-6）水平的变化情况。结果 治疗后,治疗组总有效率高于对照组,各项临床症状消失时间早于对照组,差异有统计学意义（P〈0.05）;治疗组患者血清CRP、IL-10、IL-6水平较治疗前明显下降,并显著低于对照组,差异具有统计学意义（P〈0.05）。结论 双歧三联活菌与锌剂的联合应用对小儿腹泻患者的临床疗效及恢复时间的提高,可能与患者血清CRP、IL-10、IL-6水平的降低有关。

Objective To investigate the effect of the levels of serum high sensitive C reactive protein and its clinical effect by bifidobacteria combined zinc in the treatment children with diarrhea. Methods 100 children with diarrhea from June 2013 to June 2016 in our hospital were selected and randomly divided into the control group and the experiment group, 50 cases in the control group were get general routine treatment, such as dehydration and zinc supplement, 50 cases in the experiment group were treated on the base of the control group with bifidobacteria . The clinical curative effect, the disappearance time of clinical symptoms of diarrhea and the level of serum high sensitive C reactive protein （CRP） , interleukin-10 （IL-10） and interleukin-6 （IL-6） were observed and compared between two groups. Results After treatment, the total effective rate of the treatment group was higher than that of the control group, the clinical symptoms disappeared earlier than the control group, the difference was statistically significant （P 〈 . 05）. The serum CRP, IL-10 and IL-6 levels were lower than before treatment and the experiment group was more lower, the difference was statistically ignificant （ P 〈 0. 05 ）. Conclusion The clinical efficacy and recovery time of the combined application ofbifidobacteria and zinc in children with diarrhea is related to the decrease of serum CRP, IL-10 and IL-6 levels.