小牛血去蛋白注射液联合阿司匹林用于缺血性脑卒中的临床评价及对外周血BCL-2、BAX、Caspase-3的影响

Clinical evaluation of calf blood as a combination of aspirin and aspirin for ischemic stroke and its effect on peripheral blood BCL-2, BAX and Caspase-3

目的 探讨小牛血去蛋白注射液联合阿司匹林用于缺血性脑卒中的临床评价及对外周血BCL-2、BAX、Caspase-3的影响。方法 选取2014年9月~2016年10月在三门县人民医院进行缺血性脑卒中治疗的128例患者,采取抛硬币法将其分为观察组和对照组,每组64例,对照组采用口服阿司匹林片及一些常规的内科治疗,而观察组在此基础之上增加小牛血去蛋白注射液进行治疗,分别记录2组治疗前后的血液流变学、Barthel指数、美国国立卫生研究院卒中量表（NIHSS评分）以及外周血BCL-2、BAX及Caspase-3蛋白含量。结果 治疗后,观察组患者的总有效率（96.9%）显著高于对照组的总有效率（71.9%）,观察组患者的NIHSS评分及血流变指标均明显低于对照组,观察组患者的Barthel指数显著高于对照组,观察组患者外周血BCL-2蛋白含量明显高于对照组,观察组患者外周血BAX及Caspase-3蛋白含量明显低于对照组,差异均具有统计学意义（P〈0.05）。结论 小牛血去蛋白注射液联合阿司匹林治疗缺血性脑卒中的临床效果显著,不仅可以增强患者日常生活能力,而且还可以充分改善血液流变学及外周血中的BCL-2、BAX、Caspase-3蛋白含量。

Objective To study the clinical evaluation of calf blood as a combination of aspirin and aspirin for ischemic stroke and its effect on peripheral blood BCL-2, BAX and Caspase-3 , IL-6 and pathogens. Methods 128 patients with ischemic stroke were enrolled in our hospital from September 2014 to October 2016. The patients were divided into observation group and control group by throwing coin method. The control group was treated with oral aspirin tablets and some conventional medical treatment, and the observation group on the basis of this increase in calf blood to the protein injection for treatment, the hemorheology, Barthel index, the national institutes of health stroke scale （ NIHSS score） and peripheral blood BCL-2, BAX and Caspase-3 protein content of two groups were recorded before and after treatment. Results After treatment, the total effective rate in the observation group （96. 9% ） was significantly higher than that in the control group （71. 9% ） , the NIHSS score and hemorheological index of the observation group were significantly lower than those of the control group, Bclhel index was significantly higher than that of the control group, the content of BCL-2 protein in the peripheral blood of the observation group was significantly higher than that of the control group, the levels of BAX and Caspase-3 protein in the peripheral blood of the observation group were significantly lower than those of the control group, the difference was statistically significant （ P 〈 0. 05 ）. Conclusion The clinical effect of calf blood protein injection combined with aspirin in the treatment of ischemic stroke can not only improve the daily life ability of patients, but also can improve the hemorheology and peripheral blood BCL-2 ; BAX, Caspase-3 protein content.