血府逐瘀丸对多囊卵巢综合征所致不孕女性血糖、性激素、胰岛素水平及HOMA-IR指数的影响

Effect of Xuefuzhuyu pill on blood glucose, sex hormone, insulin level and HOMA-IR index in infertile women caused by polycystic ovary syndrome

目的 分析血府逐瘀丸对多囊卵巢综合征所致不孕女性血糖、性激素、胰岛素水平及胰岛素抵抗指数（HOMA-IR）的影响。方法 选取2014年1月~2015年1月期间台州市肿瘤医院收治的多囊卵巢合并不孕的患者58例,随机分为实验组和对照组,每组各29例,对照组患者给予枸橼酸氯米芬胶囊口服治疗,实验组患者在对照组基础上给予血府逐瘀丸口服治疗,治疗周期为3个月经周期,治疗结束后,对所有患者的血清性激素水平、空腹血糖、胰岛素水平、HOMA-IR指数、子宫内膜厚度、排卵及妊娠情况进行检测。结果 治疗后,与对照组比较,实验组患者的血清黄体生成素（LH）、睾酮（T）水平均明显较低,血清促卵泡激素（FSH）、雌二醇（E2）、孕酮（P）水平明显较高,差异均有统计学意义（P〈0.05）;实验组患者的血清抗苗勒氏管激素（AMH）含量明显较低,差异有统计学意义（P〈0.05）;实验组患者的血清空腹胰岛素（FINS）水平及HOMA-IR明显较低,差异有统计学意义（P〈0.05）;实验组患者的子宫内膜厚度明显增加,卵巢体积及卵泡数量均明显下降,差异有统计学意义（P〈0.05）;实验组患者的排卵率和妊娠率较高,差异有统计学意义（P〈0.05）。结论 血府逐瘀丸能够显著降低多囊卵巢综合征合并不孕患者血清LH、T、AMH、FINS及HOMA-IR水平,使血清FSH、E2、P含量,调节性激素分泌,减轻胰岛素抵抗,提高患者排卵率和妊娠率,相比单用枸橼酸氯米芬胶囊效果更理想。

Objective To investigate the effect of Xuefuzhuyu pill on blood glucose, sex hormone, insulin levels and HOMA-IR index in patients with polycystic ovary syndrome and infertility. Methods 59 patients with polycystic ovary syndrome and infertility from January 2014 to January 2015 in our hospital were selected and randomly divided into experimental group and control group, 29 cases in each group, the control group was treated with clomiphene citrate capsules, the patients in the experimental group were given Xuefuzhuyu pill baseed on the treatment in control group, treatment period for three menstrual cycles, after the end of treatment, the levels of serum sex hormone levels, fasting blood glucose, insulin levels, HOMA index, uterine endometrial thickness, ovulation and pregnancy were detected. Results After treatment, compared with control group, in the experimental group, the serum levels of LH and T were significantly lower, and the serum levels of FSH, E2 and P were significantly higher, the difference was statistically significant （P 〈0. 05） , the serum anti-Mullerian hormone （AMH） content in the experimental group was significantly lower, the difference was statistically significant （P 〈0. 05） , the serum levels of FINS and HOMA-IR were significantly lower in the experimental group, the difference was statistically significant （ P 〈 0. 05 ） , the endometrial thickness of patients in experimental group was significantly increased, the number of follicles and ovarian volume were significantly decreased, the difference was statistically significant （P 〈 0. 05 ） , the ovulation rate and pregnancy rate in the experimental group was higher, the difference was statistically significant （P〈0. 05）. Conclusion Xuefuzhuyu pill can significantly reduce the serum LH, T, FINS, AMH and HOMA-IR levels in patients with polycystic ovary syndrome, which can improve the serum FSH, P, E2 levels, regulate sex hormone secretion, reduce insulin resistance, improve the ovulation rate and pregnancy rate, compared to single use of citric acid clomiphene capsules effect is more ideal.