阿魏酸哌嗪片联合黄芪注射液对急性肾衰竭患者β2微球蛋白、NGAL及临床疗效的影响

Effects of piperazine ferulate tablets combined with Huangqi injection on β2-microglobulin, NGAL and clinical efficacy in patients with acute renal failure

目的 探讨阿魏酸哌嗪片联合黄芪注射液对急性肾衰竭患者β2微球蛋白、NGAL及临床疗效的影响。方法 选取2012年6月~2015年10月慈溪市人民医院收治的急性肾衰竭患者56例,随机分为实验组和对照组,各28例。所有患者治疗前先进行常规护理,注入利尿剂与血管扩张剂,以增加患者的血清蛋白和维生素,从而使患者体内的酸碱度、水分及电解质达到平衡,同时给予血液透析及低分子肝素抗凝治疗。对照组在此基础上给予黄芪注射液20 m L/次,1次/天,静脉滴注,治疗4 w;实验组在对照组基础上给予阿魏酸哌嗪片200 mg/次,3次/天,治疗4 w。治疗后,比较2组患者β2微球蛋白、NGAL及KIM-1的水平。结果 2组存活率比较差异无统计学意义;治疗后,2组患者β2微球蛋白、NGAL及KIM-1水平均降低（P〈0.05）;与对照组比较,实验组患者β2微球蛋白、NGAL及KIM-1水平较低（P〈0.05）。结论 阿魏酸哌嗪片联合黄芪注射液对急性肾衰竭有较好的临床疗效,推测其机制与降低β2微球蛋白,NGAL及KIM-1水平有关。

Objective To investigate the effects of piperazine ferulate tablets combined with Huangqi injection on β2-microglobulin, NGAL and clinical efficacy in patients with acute renal failure. Methods A total of 56 patients with acute renal failure from June 2012 to October 2015 in our hospital were collected and randomly divided into the experimental group and the control group with 28 cases in each group. All patients before the treatment of conventional care, diuretics and vasodilators to increase the patient’s serum protein and vitamins,so that patients with the body’s pH, moisture and electrolyte balance, and gave hemodialysis and low molecular heparin anticoagulant therapy. Patients in the control group were treated on the base of the conventional therapy withastragalus injection 20 mL/time, one time a day, intravenous drip, treatment of four weeks ; patients in the experimental group were treated on the base of the control group with piperazine ferulate tablet 200 mg/time, three times/day, treatment of four weeks. After treatment, compared patients5 β2 microsphere protein, NGAL and KIM-1 levels. Results There was no significant difference in the survival rate between the two groups. Compared with before treatment, β2 microsphere protein, NGAL and KIM-1 levels in two groups were lower （P 〈0. 0 5 ） ; Compared with control group, β2 microsphere protein, NGAL and KIM-1 levels in the experimental group were lower （P 〈 0. 05 ） .Conclusion Piperazine ferulate tablets combine with astragalus injection in the treatment of patients with acute renal failure have a better clinical curative effect, speculate that the mechanism is relate to reduce β2 microsphere protein, NGAL and KIM-1 levels.