儿童过敏性紫癜的多药联合治疗研究

Study of multi drug combination therapy of children allergic purpura

目的 研究儿童过敏性紫癜的多药联合治疗效果。方法 选取2014年5月~2016年5月衢州市人民医院收治的过敏性紫癜患儿80例,随机分为甲强龙＋西咪替丁＋氯雷他定多药联合治疗组（治疗组）和甲强龙治疗组（对照组）,每组40例。治疗后,对2组患儿的临床疗效、皮疹消退时间、关节肿痛缓解时间、腹痛缓解时间、便血消失时间、尿常规恢复正常时间、住院时间、不良反应发生情况及复发情况进行统计分析。结果 治疗组患儿治疗总有效率为95.0%（38/40）,显著高于对照组70.0%（28/40）,差异有统计学意义（P〈0.05）;治疗组皮疹消退时间、关节肿痛缓解时间、腹痛缓解时间、住院时间均显著短于对照组（P〈0.05）,2组患儿的便血消失时间、尿常规恢复正常时间、不良反应发生率、复发率比较差异无统计学意义。结论 儿童过敏性紫癜的多药联合治疗效果比单药单独治疗更加显著,能缩短患者症状消失时间,减少住院时间。

Objective To study the effect of multi drug combination therapy of children allergic purpura. Methods 80 cases of children with Henoch Schonlein purpura in our hospital from May 2014 to May 2016 were selected, these children were randomly divided into methylprednisolone, imetidine and loratadine treatment group （treatment group） and methylprednisolone treatment group （ control group） , 40 cases in each groups, the linical curative effects, rash regression time, joint pain relief time, abdominal pain relief time, hematochezia disappeared time, urine recovery time, ospitalization time, incidences of adverse reaction and recurrences of the two groups were statistically analyzed. Results The total treatment efficiency f the treatment group was 95% （38/40）,which was significantly higher than the control group 70% （28/40） ,the difference was statistically ignificant （P 〈 0. 05 ） , the rash regression, joint pain relief time, abdominal pain relief time, hospitalization time of the treatment group were ignificantly shorter than the control group （ P 〈 0. 05 ） , but the differences the stool disappear time, urine recovery time, incidences of adverse eactions, recurrence rate between the two groups were not significant. Conclusion The effect of multi drug combination therapy of children with allergic urpura is better than single drug alone, can shorten the time of disappearance of symptoms of patients, reduce hospital stay.