匹多莫德对小儿支气管哮喘患者血清免疫细胞水平、T细胞亚群的影响

Effects of Pidomorph on serum immune cell level and T cell subsets inchildren with bronchial asthma

目的 匹多莫德对小儿支气管哮喘患者血清免疫细胞水平、T细胞亚群的影响,并分析其临床疗效。方法 选取2014年1月~2016年10月温州市苍南县人民医院收治的140例支气管哮喘患儿临床资料作为研究对象,按照入院顺序随机分为实验组与对照组,每组70例。对照组应用常规糖皮质激素药物治疗方法,实验组应用匹多莫德治疗方法。比较治疗3 w后2组患者的临床治疗总有效率、用力呼吸中速流速值、用力呼气峰速值、用力呼吸的肺活量及治疗前后血清免疫细胞水平（Ig A、Ig G、Ig M）、T细胞亚群（CD3＋、CD4＋、CD8＋）水平。结果 实验组治疗总有效率为92.86%显著高于对照组治疗总有效率72.86%（P〈0.05）;实验组患儿用力呼吸中速流速值、用力呼气峰速值、用力呼吸的肺活量显著优于对照组（P〈0.05）;治疗后,实验组患儿的血清免疫细胞水平（Ig A、Ig G、Ig M）显著高于对照组患儿（P〈0.05）;治疗后,实验组患儿的T细胞亚群（CD3＋、CD4＋、CD8＋）水平显著高于对照组（P〈0.05）。结论 匹多莫德在小儿支气管哮喘中的应用价值和安全性较高,能够有效调节T细胞亚群,改善患儿免疫功能。

Objective To evaluate the effects of Pidomorph on serum immune cell level and T cell subsets in children with bronchial asthma. Methods 140 pediatric patients with bronchial asthma from January 2014 to October 2016 in our hospital were randomly divided into experimental group and control group according to the order of admission, 70 cases in each groups. The control group was treated with conventional glucocorticoid drugs, and he experimental group was treated with pidotimod. The total effective rate of clinical treatment, the rate of rapid breathing in the flow rate, forced xpiratory peak value, forced breathing vital capacity were compared between two groups three weeks after treatment, and the serum levels of immune ells（IgA, IgG, IgM） and T cell subsets （ CD3 ＋ , CD4＋ ,CD8 ＋ ） w e r e compared b e f o r e and after t r e atment. Results T h e total effective rate w a s 2. 86% （65/70） in the experimental group and 72. 86% （51/70） in the control group, the total effective rate in the experimental group was ignificantly higher than that in the control group （ P 〈 0. 05 ） ; F o r c e d b r e a t h i n g s p e e d in the speed, f o r c e d exp i r a t o r y peak v a l u e , f o r c e d b r e a t h i n g vital apacity in the experimental group were better than the control group （ P 〈 0. 05 ） ; A f t e r t r e a t m e n t , the levels of s e r u m i m m u n e cells （IgA, IgG, I g M ） n the experimental group were significantly higher than those in the control group （ P 〈 0. 05 ） ; A f t e r t r e a t m e n t , the levels of T cell s u b s e t s （ C D 3 ＋, CD4 ＋ ,CD8 ＋ ） in the experimental group were significantly higher than those in the control group （ P 〈 0. 05 ）. Conclusion P i d o t i m o d is effective a n d afe in the treatment of bronchial asthma in children, it can effectively regulate T cell subsets and improve the immune function of children with asthma.