孟鲁司特钠咀嚼片对OSAHS患儿扁桃体及腺样体的影响

Effects of montelukast sodium chewable tablets on the tonsils and adenoids in children with OSAHS

目的 探讨孟鲁司特钠咀嚼片治疗阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患儿的疗效及对患者扁桃体及腺样体的影响。方法 选取2014年1月~2016年8月宁波市妇女儿童医院收治的OSAHS患儿84例,采用随机数字法将其分为对照组和观察组,每组各42例。对照组患儿接受常规对症治疗,在此基础上,观察组患儿接受孟鲁司特钠咀嚼片治疗。比较2组患儿的治疗总有效率,同时比较治疗前后的症状总评分、呼吸暂停低通气指数（AHI）、最低动脉血氧饱和度（LSa O2）及腺样体分级和扁桃体分度。结果 观察组的治疗总有效率（90.48%）明显高于对照组（69.04%,χ2=5.97,P〈0.05）;治疗后,观察组的症状总评分和AHI均明显低于对照组（P〈0.05）,LSa O2明显高于对照组（P〈0.05）,腺样体分级1级和2级比例明显高于对照组（χ2=9.82,P〈0.05）,扁桃体分度1度和2度比例差异无统计学意义。结论 孟鲁司特钠咀嚼片治疗OSAHS患儿的临床疗效显著,能有效缩小扁桃体和腺样体体积,对临床症状及睡眠治疗改善效果明显。

Objective To study the montelukast sodium chewable tablets for the treatment of obstructive sleep apnea hypopnea syndrome （OSAHS） patients and treatment of tonsil and adenoid effect. Methods 8 4 c a s e s of OSAHS patients in o u r hospital f r o m J a n u a r y 2 0 1 4 to A u g u s t 2 0 1 6 were randomly divided into the observation group and the control group, 42 cases in each group. The control group was treated with conventional symptomatic treatment, on this basis, the patients in the observation group received montelukast sodium chewable tablets treatment, compared the two groups of the total efficiency, and compared before and after treatment of symptoms total score, apnea hypopnealndex （AHI） , the lowest arterial oxygen saturation （LSa02） , and adenoid and tonsil classification indexing. Results t h e total efficiency o f o b s e r v a t i o n g r o u p （ 9 0 . 48% ） w a s significantly h i g h e r than the control group （69. 04% ,^2 = 5. 97, P 〈 0. 05 ） ; after t r e a t m e n t , t h e o b s e r v a t i o n g r o u p of the total symptom s c o r e and AHI w e re significantly lower than the control group （ P 〈 0. 05 ） , LSa02 was significantly higher than the control group （ P 〈 0. 05 ） , adenoid grade one and grade two were significantly higher than the control group （^2 = 9. 82 ,P 〈 0. 05 ） , t here was no significant difference between the one and t wo d e g r e e s of tonsil di v i d i n g ratio. Conclusion The clinical efficacy of montelukast sodium chewable tablets in the treatment of children with OSAHS is significant, can effectively reduce the volume of tonsil and adenoid body, and improve the clinical symptoms and sleep treatment significantly, which is worthy of clinical promotion.