辛伐他汀联合阿司匹林治疗动脉粥样硬化的疗效及对患者NMD改善情况、HDL-C、LDL-C水平的影响

Effects of simvastatin combined with aspirin on atherosclerosis and improvement of NMD in patients, HDL-C and LDL-C levels

目的 探讨辛伐他汀联合阿司匹林治疗动脉粥样硬化的治疗效果及对患者非内皮依赖性舒张功能（NMD）、血脂情况的影响。方法 回顾性分析2014年8月~2016年5月于天津市宝坻区人民医院接受治疗的95例动脉粥样硬化患者的临床资料,根据其治疗方式分为辛伐他汀组（n=45）和联合治疗组（n=50）,辛伐他汀组给予辛伐他汀治疗,联合治疗组在此基础上给予阿司匹林治疗。治疗4 w后,观察2组患者治疗前后斑块数量、NMD和血脂情况的差别。结果 治疗后,联合治疗组的斑块大小和数量均较辛伐他汀组小,差异有统计学意义（P〈0.05）;联合治疗组的NMD水平明显高于辛伐他汀组,差异有统计学意义（P〈0.05）;联合治疗组的白细胞介素-18（IL-18）、白细胞介素-6（IL-6）和超敏C反应蛋白（hs-CRP）低于辛伐他汀组,差异有统计学意义（P〈0.05）;联合治疗组的低密度脂蛋白胆固醇（LDL-C）、甘油三酯（TG）、总胆固醇（TC）水平低于辛伐他汀组,高密度脂蛋白胆固醇（HDL-C）水平高于辛伐他汀组,差异有统计学意义（P〈0.05）。结论 辛伐他汀与阿司匹林联合应用可明显改善动脉粥样硬化患者非内皮依赖性舒张功能和血脂水平,具有较好的治疗效果。

Objective To investigate the effect of simvastatin and aspirin on atherosclerosis and its effect on non endothelium dependent diastolic unction （ NMD） and blood lipid in patients. Methods R e t r o s p e c t i v e a n a l y z e d a total of 95 the clinical d a t a of patients w i t h atherosclerosis treated in ianjin Baodi Hospital from August 2014 to May 2016. The patients were divided into simvastatin group and combined treatment group according to their reatment methods, simvastatin group was given simvastatin, combined treatment group was given aspirin on the basis of simvastatin. After four weeks reatment, the difference of plaque quantity, NMD and blood lipid between the two groups were observed. Results A f t e r t r e a t m e n t , the size a n d n u m b e r f plaques in the combined treatment group were smaller than those in the simvastatin group, the difference was statistically significant （ P 〈 0. 05 ） , the NMD level in the combined treatment group was significantly higher than that in the simvastatin group, the difference was statistically significant （P 〈 . 05） , the levels of IL-18, IL-6 and hs-CRP in the combined treatment group were lower than those in the simvastatin group, the difference was tatistically significant （P 〈0. 05） , the levels of LDL-C, TG and TC in the combined treatment group were lower than those in the simvastatin group, HDL-C levels were higher than simvastatin group, the difference was statistically significant （ P 〈 0. 05 ）. Conclusion Simvastatin combined with aspirin an significantly improve the endothelium dependent diastolic function and lipid level in patients with atherosclerosis, and has good therapeutic effect.