奥美拉唑与蝮蛇血凝酶针对胃溃疡血清血管内皮生长因子、上皮生长因子水平变化及临床疗效分析

Clinical effect analysis of blood coagulation therapy in patients with gastric ulcer bleeding treated by omeprazole and Agkistrodon acutus venom and changes of serum vascular endothelial growth factor and epidermalgrowth factor levels in serum

目的 探讨胃溃疡出血患者应用蝮蛇血凝酶针治疗的临床效果。方法 选取2013年1月~2016年1月在浙江省杭州市萧山区第一人民医院诊治的150例胃溃疡出血患者,采用SPSS16.0软件生成随机数字分为蝮蛇血凝酶针组（基础治疗＋蝮蛇血凝酶针注射治疗）和对照组（基础治疗）各75例,对比2组的止血时间、止血效果。结果 治疗72 h后,蝮蛇血凝酶针组患者的平均止血时间显著的低于对照组（P〈0.05）;蝮蛇血凝酶针组患者的血清血管内皮生长因子（vascular endothelial growth factor,VEGF）、上皮生长因子（epidermal growth factor,EGF）水平高于对照组（P〈0.05）,胃泌素、生长抑素水平低于对照组（P〈0.05）;蝮蛇血凝酶针组患者的止血痊愈率64.00%、显效22.67%、有效9.33%、无效4.00%,对照组分别为46.67%、25.33%、18.67%、9.33%,2组比较差异具有统计学意义（P〈0.05）。结论 胃溃疡出血患者应用蝮蛇血凝酶针治疗能够缩短止血时间、提高止血的临床效果。

Objective To investigate the clinical effect of coagulation therapy in patients with gastric ulcer bleeding. Methods F r o m J a n u a r y 2 0 1 3 to January 2016 in Xiaoshan First People’s hospital 150 cases of gastric ulcer patients with bleeding, using SPSS16. 0 software to generate randomly divided into hemocoagulase group （basic treatment ＋ hemocoagulase injection therapy） and control group （basic treatment） of the 75 cases, compared two groups of hemostatic time, hemostatic effect. Results A f t e r 72 h t r e a t m e n t , the a v e r a g e h e m o s t a s i s t i m e o f h e m o c o a g u l a s e g r o u p w e re significantly lower than the control group （P 〈0. 05） , the blood coagulation enzyme in patients with serum VEGF, EGF levels higher than the control group （P 〈 0. 05 ） , gastrin and somatostatin levels lower than the control group （P 〈0. 05） , hemocoagulase group cure rate is 64% , effective in 22. 67% , effective 9. 33% , invalid 4% , the control group were 46. 67% , 25. 33% , 18. 67% , 9. 33% , two groups compare difference was statistically significant （P 〈 0. 05）. Conclusion Treatment of gastric ulcer bleeding patients with coagulation enzyme can shorten the hemostatic time, improve the clinical effect of hemostasis.