摘要
目的 探讨胃溃疡出血患者应用蝮蛇血凝酶针治疗的临床效果。方法 选取2013年1月~2016年1月在浙江省杭州市萧山区第一人民医院诊治的150例胃溃疡出血患者,采用SPSS16.0软件生成随机数字分为蝮蛇血凝酶针组(基础治疗+蝮蛇血凝酶针注射治疗)和对照组(基础治疗)各75例,对比2组的止血时间、止血效果。结果 治疗72 h后,蝮蛇血凝酶针组患者的平均止血时间显著的低于对照组(P〈0.05);蝮蛇血凝酶针组患者的血清血管内皮生长因子(vascular endothelial growth factor,VEGF)、上皮生长因子(epidermal growth factor,EGF)水平高于对照组(P〈0.05),胃泌素、生长抑素水平低于对照组(P〈0.05);蝮蛇血凝酶针组患者的止血痊愈率64.00%、显效22.67%、有效9.33%、无效4.00%,对照组分别为46.67%、25.33%、18.67%、9.33%,2组比较差异具有统计学意义(P〈0.05)。结论 胃溃疡出血患者应用蝮蛇血凝酶针治疗能够缩短止血时间、提高止血的临床效果。
Objective To investigate the clinical effect of coagulation therapy in patients with gastric ulcer bleeding. Methods F r o m J a n u a r y 2 0 1 3 to January 2016 in Xiaoshan First People’s hospital 150 cases of gastric ulcer patients with bleeding, using SPSS16. 0 software to generate randomly divided into hemocoagulase group (basic treatment + hemocoagulase injection therapy) and control group (basic treatment) of the 75 cases, compared two groups of hemostatic time, hemostatic effect. Results A f t e r 72 h t r e a t m e n t , the a v e r a g e h e m o s t a s i s t i m e o f h e m o c o a g u l a s e g r o u p w e re significantly lower than the control group (P 〈0. 05) , the blood coagulation enzyme in patients with serum VEGF, EGF levels higher than the control group (P 〈 0. 05 ) , gastrin and somatostatin levels lower than the control group (P 〈0. 05) , hemocoagulase group cure rate is 64% , effective in 22. 67% , effective 9. 33% , invalid 4% , the control group were 46. 67% , 25. 33% , 18. 67% , 9. 33% , two groups compare difference was statistically significant (P 〈 0. 05). Conclusion Treatment of gastric ulcer bleeding patients with coagulation enzyme can shorten the hemostatic time, improve the clinical effect of hemostasis.
出处
《中国生化药物杂志》
CAS
2017年第4期336-338,共3页
Chinese Journal of Biochemical Pharmaceutics
关键词
胃溃疡
出血
蝮蛇血凝酶针
gastric ulcer
hemorrhage
hemagglutination enzyme