甲氨蝶呤联合雷公藤多甙对类风湿性关节炎干预的整体疗效研究

Research on the overall effect of methotrexate combined with multiglycosides of tripterygium wilfordiion the clinical intervention ofrheumatoid arthritis

目的 研究甲氨蝶呤联合雷公藤多甙对类风湿关节炎临床干预的整体疗效。方法 选择浙江省长兴县人民医院治疗的96例类风湿性关节炎患者作为研究对象,随机分为对照组与研究组,每组48例。在2组患者均予以基础治疗的前提下,对照组给予甲氨蝶呤治疗,研究组予以甲氨蝶呤联合雷公藤多甙治疗。治疗3个月后,评估2组患者的临床症状、实验室指标、医生与患者对疾病活动性总体评价,同时观察用药的安全性。结果 对比2组治疗前,各项临床症状、实验室指标以及医生、患者对疾病活动性总体评价等均无显著差异,治疗后各组指标均显著好转（P〈0.05）,试验组各项指标均显著优于对照组（P〈0.05）。对照组与研究组分别有4例（8.3%）、6例（12.5%）出现胃肠道反应,组间差异无统计学意义。结论 甲氨蝶呤联合雷公藤多甙对类风湿性关节炎进行临床干预,可获得较为满意的整体疗效,患者的关节疼痛、肿胀等症状以及炎症指标改善显著,且安全性较高,值得临床应用。

Objective To study the the overall effect of methotrexate combined with multi-glycosides of tripterygium wilfordii on the clinical ntervention of rheumatoid arthritis. Methods In Changxing county peopled hospital, 96 cases with rheumatoid arthritis were selected as the research object, which were randomly divided into the the control group and the study group, 48 cases in each group. On the basis of the basic treatment in the two groups, the control group were given methotrexate, the experimental group were given methotrexate combined with multi-glycosides of tripterygium wilfordii. 3 months after treatment, the clinical symptoms, the laboratory index and assessment of disease activity by physicians and patients were evaluated. The drug safety was observed. Results Before treatment, The clinical symptoms, laboratory index and physician and assessment of disease activity by physicians and patients showed no significant differences between the two groups . All the indexes in the two groups after treatment were mproved （P 〈 0. 05 ） . Compared with the control group, all the indexes in the study group were better （ P 〈 0. 05 ） . There were 4 cases （8. 3% ） gastrointestinal adverse reaction in the control group and 6 （ 12. 5% ） in the study group. There was no significant difference about adverse reaction between the two groups. Conclusion It can obtain satisfactory overall effect that methotrexate combined with multi-glycosides of tripterygium wilfordii on he clinical intervention of rheumatoid arthritis which is safty. The joint pain, swelling and other symptoms and inflammatory index were significantly mproved. It is worthy of clinical application.