哮喘气道重塑患者HRCT的表现与气道炎症程度的关系研究

Relationship between HRCT expression and airway inflammation in patients with asthma airway remodeling

目的 研究高分辨螺旋CT对哮喘气道重塑患者气道炎症的评估。方法 回顾分析金华广福医院60例慢性持续期哮喘患者行诱导痰IL-4检测、高分辨螺旋CT扫描,对照组20例仅做高分辨螺旋CT扫描。比较不同严重程度哮喘患者的诱导痰IL-4、HRCT测试的气道壁厚度（wall thickness,WT）、管壁面积（wall area,WA）和气道壁相对面积（wall relative area,WA%）有无差异。结果不同程度的哮喘患者WT、WA、WA%均较对照组显著增加（P〈0.05）,各组之间有差异有统计学意义（P〈0.05）。WT和WA%与诱导痰IL-4呈正相关。结论 高分辨螺旋CT能有效评估哮喘气道重塑患者的气道炎症程度,可用于评估哮喘的严重性、治疗效果和随访观察。

Objective To study the assessment of airway inflammation in asthma patients with airway remodeling by high resolution spiral CT （HRCT）. Methods Retrospective analysis on 60 cases of chronicity-persistent period asthma patients with induced sputum IL-4 test, airway mucosa iopsy, HRCT scan; while 20 patients only used HRCT scan as control group. To compare the difference of sputum IL-4, HRCT test of airway wall hickness （WT） , wall area （WA） and airway wall relative area （WA% ） in different degrees of asthma paitents. Results WA, WA% and WT were ignificantly increased in different degrees of asthma patients when compared to control group （ P 〈 0. 05 ） , there were significant difference among each roup （P 〈 0. 05 ） . WA% and WT were positively correlated with induced sputum IL4. Conclusion HRCT can effectively evaluate the airway nflammation in airway remodeling of asthma patients, which can be used to evaluate the severity of asthma, treatment effect and follow-up observation.