摘要
本文简要综述了抗体介导的靶向给药系统的研究进展,包括抗体与药物的直接偶联、纳米粒、脂质体等的原理、特性以及药动药效学研究现状,并对其可行性和前景进行了分析。抗体介导的靶向给药系统不仅可以提高不溶或难溶性药物的溶解度,而且也可以提高靶部位的药物浓度,降低药物对全身各组织的毒副作用,增强对病变组织的治疗效果,为开发更高靶向效率、安全、经济、多类型的给药系统提供了借鉴。
In this paper, the research progress of antibody-mediated targeting drug delivery system, including the targeting principal, efficiency, pharmacokinetics as well as pharmacodynamics of antibody drug conjugates, nanoparticles and liposomes, were summarized. Its feasibility and prospect in drug delivery system were analyzed. Antibody-mediated targeting drug delivery system not only improves the solubility of insoluble or poorly soluble drugs, but also accumulates the drug at targeted sites, increases the therapeutic effect of lesion and decreases toxicity. It can help for the development of kinds of targeted drug delivery system with high targeting efficiency, safety and economy.
出处
《生物技术通讯》
CAS
2017年第2期196-201,共6页
Letters in Biotechnology
关键词
抗体
靶向
纳米粒
脂质体
抗体药物偶联
antibody
target
nanoparticles
liposomes
antibody drug conjugates
