Sema4D表达在慢性病毒持续感染中的作用机制研究进展

Advances of Sema4D Expression in Chronic Viral Infections

Sema4D又称CD100是近年新发现的重要的免疫调节分子,Sema4D与其受体plexin-B1和CD72结合,通过多种信号转导途径,在神经系统的轴突导向,肿瘤的侵袭转移和免疫系统中T、B细胞的活化和免疫调节中发挥关键作用。最新研究表明,Sema4D在慢性病毒持续感染中发挥重要作用,Sema4D对维持CD8^+T细胞的功能尤为重要,Sema4D对控制感染慢性化至关重要。Sema4D作为监测T细胞免疫功能的关键标志分子,可能参与慢性病毒感染性疾病T细胞功能低下。我们就Sema4D表达在慢性病毒持续感染中的作用机制方面的研究进展做简要综述。

Sema4D, also known as CD100, was the first discovered immune semaphonrin. Sema4D binding its receptor plexin-B1 and CD72 plays a key role in the axon guidance of nervous system, tumor metastasis and activation and immune regulation of T, B cells in the immune system through a variety of signal transduetion pathways. To date, accumulating evidences have indicated that Sema4D has a pivotal funetion during ehronic viral infection and Sema4D is particularly crucial in the control of chronic infection by maintaining CD8^＋ T cell functions. Sema4D as a key marker of T cell immune function may involve in the T cell exhaustion in chronic viral infections. The following is a brief overview of the recent advance in the role of Sema4D expression in chronic viral infections.