血清降钙素原CRP与WBC在颅脑手术患者发热中的诊断价值分析

The Effects of WBC CRP and WBC on Diagnosing Brain Surgery Patients with Fever

目的:研究颅脑手术发热患者采用血清降钙素(PCT)、C反应蛋白(CRP)以及白细胞(WBC)诊断的临床价值。方法:临床纳入我院2014年8月至2015年8月期间收治的98例颅脑手术后发热患者,根据患者有无感染情况分为两组。其中有感染的患者46例作为感染组,无感染的患者52例作为未感染组。另选取同期进行颅脑手术后未出现发热的患者50例作为对照组。对三组患者PCT、CRP以及WBC水平进行检查,观察对颅脑手术发热的诊断价值。结果:感染组、未感染组患者CRP、WBC水平均高于对照组(P<0.05);对照组、未感染组PCT水平无差异(P>0.05);感染组PCT水平均高于两组(P<0.05)。PCT指标的灵敏度、特异度均高于CRP和WBC,而ROC下曲线面积也更接近于1,均P<0.05。结论:PCT对颅脑手术后发热的病原学诊断效果明显高于CRP和WBC,尤其是对细菌感染性发热诊断价值更高,可作为临床诊断的常用指标。

Objective： To discuss the effects of WBC,CRP and WBC on diagnosing brain surgery patients with fever. Methods： 98 brain surgery patients with fever who accepted treatment in our hospital from Aug.2014 to Aug. 2015 were included in this study and divided into two groups according to the infection degree. 46 patients were in the infection group and 52 cases in non-infection group. On the other hand,50 patients accepted brain surgery patients without fever were selected as control group. Results： The CRP,WBC level of infection group and non-infection grouop were significantly higer than those of the control group（ P 〈0.05）. There was no significant different between the control group and non-infectin group of the PCT level（ P 〉0.05） whereas the PCT level of infection group was significant higher than the other two group（ P 〈0.05）. The sensitivity and specificity of PCT were significantly higher than CPR and WBR（ P 〈0.05）,and the area under ROC curve was close to 1. Conclusion： PCT has the better diagnosing effect comparing to CRP and WBC,especially when patients with fever,which could be the main index of the clinical diagnosis.