腹腔镜手术与开腹手术对重症急性胰腺炎外周血T淋巴细胞亚群的影响比较

Comparing the Impact of Laparoscopic Surgery with Open Surgery for Severe Acute Peripheral Blood T Lymphocyte Subsets

目的:分析腹腔镜手术与开腹手术对重症急性胰腺炎外周血T淋巴细胞亚群的影响。方法:选取于我院就治急性胰腺炎患者98例,随机分为两组,对照组(49例),实验组49(例)。对照组患者接受普通开腹手术;而观察组患者接受腹腔镜手术。结果:治疗后,观察组患者Lym、CD3+和CD4+水平显著高于对照组患者Lym、CD3+和CD4+水平;另外,在CD8+水平方面,观察组患者显著低于对照组患者(P<0.01)。同时,观察组患者Ang-Ⅱ、Ang-Ⅲ、ALD水平显著低于对照组患者,差异具有统计学意义(P<0.01),观察组患者IL-6、PCT、hs-CRP水平均显著低于对照组患者(P<0.01)。结论:腹腔镜手术治疗重症急性胰腺炎效果明显,具有伤口小、操作简单、恢复快等优点,能够有效的恢复患者免疫功能,提高治疗效果,改善患者生活质量。

Objective： To analyze the impact of laparoscopic surgery and open surgery for severe acute peripheral blood T lymphocyte subsets. Methods： 98 cases of patients with severe acute pancreatitis were selected and divided into control group（ 49 cases） and observation group（ 49 cases）. The patients in control group were treated with open surgery,patients in the observation group were treated with laparoscopic surgery.Results： The level of the Lym,CD3 ＋ and CD4 ＋ of the patients in the observation group were significantly higher than those of the patients in control group,whereas the level of CD8＋ of the patients in the observation group were significantly lower than those of the patients in control group（ P 〈0.01）. Furthermore,the level of Ang-Ⅱ,Ang-Ⅲ,ALD of the patients in the observation group were significantly lower than that of the patients in control group（ P 〈0.01） and the level of IL-6,PCT,hs-CRP of the patients in the observation group were significantly lower than that of the patients in control group（ P 〈0.01）. Conclusion： Laparoscopic treatment of severe acute pancreatitis have obviously effect,advantages of the wound is small,simple and quick recovery,can effectively restore immune function in patients,improve the therapeutic effect,also can improve the quality of life of patients.