肠内喷洒溃结灵对溃疡性结肠炎患者肠道粘膜免疫功能及炎症因子水平的影响

Effect of Enteral Spray of Kuijieling on the Intestinal Mucosal Immune Function and Levels of Inflammatory Factors in Patients with Ulcerative Colitis

目的:分析肠内喷洒溃结灵对溃疡性结肠炎(UC)患者肠道粘膜免疫功能及炎症因子水平的影响。方法:将90例UC患者随机分为实验组(n=45)和对照组(n=45)。对照组予以口服柳氮磺吡碇胶囊治疗,实验组在对照组基础上予以肠内喷洒溃结灵干预。治疗前后观察两组肠镜下溃疡、糜烂及出血点改善情况,行血清免疫、炎症因子指标检测,包括免疫球蛋白(Ig G、Ig M、Ig A)、T细胞亚群CD4+、CD8+和肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)等。结果:两组治疗前肠镜检查结果比较差异无统计学意义(P>0.05),治疗后肠镜下溃疡、糜烂及出血点发生率均降低(P<0.05),且实验组治疗后肠镜下溃疡、糜烂及出血点发生率4.44%、11.11%、8.88%低于对照组17.78%、28.89%、24.44%(P<0.05)。两组治疗前各项免疫球蛋白、T细胞亚群CD4+、CD8+及血清炎症因子水平比较无统计学意义(P>0.05),治疗后上述指标水平均较治疗前改善(P<0.05),且实验组治疗后Ig G、Ig M、Ig A、CD8+水平高于对照组,CD4+低于对照组(P<0.05),TNF-α、IL-1β水平低于对照组,IL-4、IL-10水平高于对照组(P<0.05)。结论:肠内喷洒溃结灵可显著增强临床UC治疗效果,改善肠镜下溃疡、糜烂状况,增强肠道粘膜免疫功能及调控炎症因子水平。

Objective： To analyze the effect of enteral spray of Kuijieling on the intestinal mucosal immune function and levels of inflammatory factors in patients with ulcerative colitis（ UC）.Methods： Ninety patients with UC were randomly divided into the experimental group（ n = 45） and the control group（ n = 45）.The control group was treated with oral administration of sulfasalazinecapsule while the experimental group was additionally treated with enteral spray of Kuijieling. The relief of endoscopic ulcer,erosion and bleeding points was observed before and after treatment. The serum immunological and inflammatory factors,including immunoglobulins（ Ig G,Ig M,Ig A）,T cell subsets（ CD4＋,CD8＋）,tumor necrosis factor α（ TNF-α）,interleukin-1β（ IL-1β） were detected.Results： The results of endoscopy showed no significant differences between the two groups before treatment（ P 〉 0.05）. After treatment,the incidence rates of endoscopic ulcer,erosion and bleeding were significantly decreased（ P 〈 0.05）,and the incidence rates in experimental group（ 4.44%,11.11%,8.88%） were significantly lower than those in the control group（ 17.78%,28.89%,24.44%）（ P 〈0.05）. Before treatment,the immunoglobulins,T cell subsetsand levels of serum inflammatory factors showed no significant differences between the two groups（ P 〉 0.05）. After treatment,the above indexes were significantly improved（ P 〈 0.05）,and the levels of Ig G,Ig M,Ig A,CD8＋,IL-4 and IL-10 in the experimental group were significantly higher than those in the control group while the levels CD4 ＋,TNF-α and IL-1βwere significantly lower than those in the control group（ all P 〈 0.05）.Conclusion： Enteral spray of Kuijieling can significantly enhance the clinical therapeutic effect of UC,relieve endoscopic ulcer and erosion,enhance theintestinal mucosal immune function and regulate the levels of inflammatory factors.