2型糖尿病肾病患者血尿酸与炎症因子的相关性研究

Correlation Study of the Levels of Uric Acid With Inflammation Factor in Type 2 Diabetes

目的:探讨2型糖尿病肾病患者血尿酸水平与炎症因子的相关性。方法:选取2型糖尿病(T2DM)患者107例,根据尿白蛋白/肌酐(ACR)分为正常尿蛋白组39例、微量蛋白尿组38例,临床蛋白尿组30例。检测三组受检者的血尿酸(UA)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)及细胞间粘附分子-1(ICAM-1)的水平。结果:三组受检者UA及CRP、TNF-α、ICAM-1水平比较,差异均据有统计学意义(P<0.05),且正常蛋白尿组、微量蛋白尿组、临床尿蛋白组UA及CRP、TNF-α、ICAM-1水平均逐渐升高,组间两两比较差异均具有统计学意义(P<0.05)。相关性分析显示,三组受检者UA与CRP、TNF-α、ICAM-1水平均呈正相关(r分别=0.949,0.846,0.934,P<0.05)。结论:在2型糖尿病患者,血尿酸通过炎症反应参与了糖尿病肾病的发病机制。

Objective： To investigate the correlation of the levels of uric acid with inflammation factor in type 2 diabetes. Methods： One hundred and seven cases of patients with type 2 diabetes were divided into contral group,microalbuminuria group and clinical proteinuria group according to urinary albumin to creatinine ratio,the levels of uric acid and C-reactive protein were detected. Results： The levels of uric acid and C-reactive protein,TNF-α,ICAM-1 of contral group,microalbuminuria group and clinical proteinuria group were on the rise,the differences were statistically significant（ P 〈0.05）,the levels of uric acid with C-reactive protein,TNF-α,ICAM-1 were positively correlated. Conclusion： Uric acid leading to diabetic nephropathy through inflammatory reaction in type 2 diabetes.