神经妥乐平联合脾氨肽治疗带状疱疹疗效观察

Clinical Effect of Neurotropin Injection Combined with Spleen Aminopeptide in the Treatment of Herpes Zoster

目的:观察早期使用神经妥乐平联合脾氨肽口服冻干粉治疗带状疱疹的疗效。方法:将60例带状疱疹早期患者随机分为两组,治疗组和对照组各30例。对照组给予阿昔洛韦0.25g/q8h静脉滴注联合腺苷钴胺针1.0mg/qd肌注,治疗组在对照组基础上加用神经妥乐平3.6IUqd静脉滴注再联合脾氨肽口服冻干粉2mg/qd口服,疗程10d。采用视觉模拟评分法(VAS)法评估患者疼痛程度,采用睡眠质量评分法(QS)法评估患者睡眠质量,对比两组治疗前后VAS及QS评分变化以观察神经痛改善的效果。结果:两组治疗后较治疗前VAS评分均下降显著,QS评分均上升显著,差异均有统计学意义(P<0.001),治疗组VAS评分明显低于对照组,QS评分明显高于对照组,差异均有统计学意义(P<0.001)。结论:早期应用神经妥乐平联合脾氨肽口服冻干粉治疗带状疱疹更能有效改善患者神经疼痛的症状,从而提高患者生活质量。

Objective： To explore the clinical effect of Neurotropin and spleen aminopeptide oral lyophilized powder in the treatment of herpes zoster. Methods： 60 patients with herpes zoster at early stage were randomly divided into two groups： treatment group and control group,30 cases in each group. The control group were given acyclovir for a 0.25 g intravenous drip every 8 hours and cobamamide needle for 1.0 mg intramuscular injection everyday. On the basis of the treatment in the control group,treatment group were given Neurotropin 3.6IU on an intravenousdrip and spleen peptide oral lyophilized powder producing 2 mg by oral a day,the treatment course was 10 days.The pain degree of the patients was assessed by the methods of visual analogue scale（ VAS）,The sleep quality of the patients was determined by the methods of sleep quality score（ QS）,VAS and QS score changes the two groups before and after treatment were compared,the improved effect of neuralgia was observed. Results： VAS score of the two groups all significantly decreased before and after the treatment,QS score increased significantly,the difference was statistical significant（ P 〈 0. 05）.VAS score of the treatment group was significantly lower than that of the control group,while QS score of the treatment group was significantly higher than that of the control group,the difference was statistically significant（ P 〈0.001）. Conclusion： The application of Neurotropin injection combined with spleen peptide on the treatment of herpes zoster at early stage can effectively improve the symptom of neuralgia patients,then consequently improve the life quality of patients.