尿激酶联合YL-1型血肿穿刺针微创治疗对高血压脑出血患者血糖及血清CRP的影响

Effect of urokinase in combined with minimally invasive hematoma puncture with YL-1 type needle on the blood sugar and serum CRP in patients with hypertensive cerebral hemorrhage

目的:观察尿激酶联合YL-1型血肿穿刺针微创治疗高血压脑出血的临床疗效及对患者血糖、血清C-反应蛋白(CRP)的影响。方法:选取广西蒙山县中医院收治的高血压脑出血患者84例,依据治疗方案不同分为微创组53例及保守组31例;2组入院后均进行常规药物治疗,微创组根据患者病情择期行尿激酶联合YL-1型血肿穿刺针微创治疗,对比2组治疗前后血糖及血清CRP水平动态变化,并CT复查脑血肿及水肿体积变化。结果:微创组在治疗后3d、7d、14d血清CRP及血糖水平明显低于保守组(P<0.05);微创组在治疗后1d、3d、7d、14d脑血肿及水肿体积均显著低于保守组(P<0.05)。结论:尿激酶联合YL-1型血肿穿刺针微创治疗可显著减轻高血压脑出患者脑组织损伤,降低全身炎症反应及机体血糖水平,利于患者康复。

Objective：To observe the clinical efficacy of urokinase in combined with minimally invasive hematoma puncture with YL-1type needle in the treatment of hypertensive cerebral hemorrhage and the effect on blood sugar and serum CRP.Methods：A total of 84 patients with hypertensive cerebral hemorrhage who were admitted in our hospital were included in the study and divided into the minimally invasive group（n=53）and the conservative group（n=31）according to different treatment protocols.The patients in the two groups were given routine drug treatments.The patients in the observation group were given urokinase in combined with minimally invasive hematoma puncture with YL-1type needle.The blood sugar and serum CRP levels before and after treatment in the two groups were compared.CT was performed to reexamine the cerebral hematoma and edema volume.Results：The serum CRP and blood sugar levels 3d,7d,and 14 dafter treatment in the minimally invasive group were significantly lower than those in the conservative group（P〈0.05）.The cerebral hematoma and edema volume 1d,3d,7d,and 14 dafter treatment in the minimally invasive group was significantly lower than that in the conservative group（P〈0.05）.Conclusions：Urokinase in combined with minimally invasive hematoma puncture with YL-1type needle in the treatment of hypertensive cerebral hemorrhage can significantly alleviate the brain tissue injury,reduce the systemic inflammatory reaction and blood sugar level,and contribute to the rehabilitation.