影响瞬时弹性成像诊断肝纤维化分期因素的研究进展

Progression of influencing factors on liver fibrosis staging by transient elastography

肝纤维化是多种慢性肝脏疾病的共同终点,肝纤维化可进展为肝硬化、肝衰竭、肝癌,从而导致死亡,肝纤维化和肝硬化的准确诊断对于肝脏疾病的预测、干预和预后至关重要。瞬时弹性成像(transient elastography;TE)作为基于肝脏硬度测量的无创方法之一,与传统肝脏组织活检相比具有诸多优势,广泛应用于慢性肝脏疾病患者的肝纤维化分期诊断;但是,体内外诸多因素可影响肝脏硬度值和TE结果以及慢性肝脏疾病的临床管理。因此,本文着重介绍影响肝脏硬度和瞬时弹性成像检查结果的关键因素。

Liver fibrosis is the common end-point of a variety of chronic liver diseases. Liver fibrosis can prog-ress to cirrhosis, liver failure and hepatocellular carcinoma, which can result in death. Accurate diagnosis of liver fibrosis and cirrhosis is essential for prognostication of liver disease and for timely intervention to prevent negative outcome. Transient elastography （TE） as one of the most validated non-invasive methods based on liver stiffness measurement （LSM）, as compared with conventional liver biopsy, has many advantages, and is widely used in patients with chronic liver diseases for liver fibrosis staging. However, many factors in vivo and vitro can affect the LSM thus affecting the con-sequence of the clinical management of chronic liver disease and results of TE. Therefore, this review focuses on the key factors influencing liver stiffness and TE findings.