8-羟基脱氧鸟苷在氧化应激与儿童相关疾病的研究

Research progress of 8-hydroxy-2′-deoxyguanosine in oxidative stress and childhood-related diseases

8-羟基脱氧鸟苷(8-OHdG)是DNA氧化损伤产物之一。8-OHdG水平可反映机体氧化损伤程度,是目前国际上公认的评价DNA氧化损伤和氧化应激(OS)状态的新型指标和生物标志物。笔者拟就8-OHdG的主要检测方法及其在OS与儿童相关疾病的最新研究进展进行阐述,旨在为临床对该类疾病的诊断与治疗提供参考依据。

As we know, 8-hydroxy-2′-deoxyguanosine （8-OHdG） is one of the oxidative damage products of DNA. The level of 8-OHdG can reflect the degree of oxidative damage in the body, and it is recognized internationally as one of new indicators and biomarkers for evaluating DNA oxidative damage and oxidative stress （OS） state. This study will focus on the detection method of 8-OHdG, and the research progress of 8-OHdG in OS and childhood-related diseases, in order to provide a reference for the diagnosis and treatment of those disease.