热性惊厥患儿血清Ca^(2+)水平与神经损伤、心肌损伤程度的关系

Relationship between serum Ca^(2+) level and nerve injury as well as myocardial injury in children with febrile convulsion

目的:探讨热性惊厥患儿血清Ca^(2+)水平与神经损伤、心肌损伤程度的关系。方法:选取在本院接受治疗的热性惊厥患儿32例作为观察组,另取同期在本院进行疫苗接种的健康小儿30例作为正常对照组。检测两组小儿血钙水平,根据观察组血钙水平中位数进一步分为高血Ca^(2+)组16例、低血Ca^(2+)组16例。对比观察组不同血钙患儿神经损伤、心肌损伤程度的差异。结果:观察组血清Ca^(2+)水平低于正常对照组(P<0.05);低血Ca^(2+)组外周血兴奋性氨基酸Glu、Asp、Lys、Ser含量高于高血Ca^(2+)组,抑制性氨基酸Gly、GABA含量低于高血Ca^(2+)组(P<0.05);低血Ca^(2+)组患儿心功能参数SV、CI、Vpk水平低于高血Ca^(2+)组,SVR水平高于高血Ca^(2+)组(P<0.05);低血Ca^(2+)组外周血心肌酶谱指标CK-MB、LDH、α-HBDH含量高于高血Ca^(2+)组(P<0.05)。结论:热性惊厥患儿血清Ca^(2+)水平较低,且Ca^(2+)水平与神经损伤、心肌损伤程度呈负相关。

Objective：To study the relationship between serum Ca^2＋ level and nerve injury as well as myocardial injury in children with febrile convulsion.Methods：A total of 32 children with febrile convulsion treated in our hospital between May2011 and September 2015 were selected as observation group and 30 healthy children receiving vaccination in our hospital during the same period were selected as normal control group.Blood calcium levels of two groups of children were detected,and the median blood calcium level was referred to further divide the observation group into high blood Ca^2＋ group（n=16）and low blood Ca^2＋ group（n=16）.The differences in nerve injury and myocardial injury were compared between children with blood calcium levels within observation group.Results：Serum Ca^2＋ level of observation group was lower than that of normal control group（P〈0.05）;excitatory amino acids Glu,Asp,Lys and Ser contents in peripheral blood of low blood Ca^2＋ group were higher than those of high blood Ca^2＋ group while inhibitory amino acids Gly and GABA contents were lower than those of high blood Ca^2＋ group（P〈0.05）;cardiac function parameters SV,CI and Vpk levels of low blood Ca^2＋ group were lower than those of high blood Ca^2＋ group while SVR level was higher than that of high blood Ca^2＋ group（P〈0.05）;myocardial enzyme spectrum indexes CK-MB,LDH andα-HBDH contents in peripheral blood of low blood Ca^2＋ group were higher than those of high blood Ca^2＋ group（P〈0.05）.Conclusion：Serum Ca^2＋ level is low in children with febrile convulsion and Ca^2＋ level is negatively correlated with nerve injury and myocardial injury.