微创血肿清除术联合醒脑静治疗对高血压脑出血患者神经功能损伤及细胞因子含量的影响

Effect of minimally invasive evacuation of hematoma combined with Xingnaojing therapy on neurological function injury and cytokine level in patients with hypertensive cerebral hemorrhage

目的:研究微创血肿清除术联合醒脑静治疗对高血压脑出血患者神经功能损伤及细胞因子含量的影响。方法:收集在本院接受治疗的高血压脑出血患者80例作为研究对象,回顾其治疗方法及检查结果,分为接受单纯微创血肿清除术治疗的对照组45例、接受微创血肿清除术联合醒脑静治疗的观察组35例。治疗前后,采用脑血流检测仪检测脑血流参数;采用ELISA法检测血清中神经功能指标、炎症因子的含量;采用高效液相色谱仪检测血清中神经递质的含量。结果:治疗前,两组脑血流参数、神经功能指标、炎症因子、神经递质的差异无统计学意义(P>0.05)。治疗后,观察组脑血流参数Q、V的水平高于对照组,R的水平低于对照组(P<0.05);观察组血清中NSE、NPY、IL-1β、IL-4、IL-6、TNF-α、Glu、Asp的含量低于对照组,BDNF、Gly的含量高于对照组患者(P<0.05)。结论:微创血肿清除术联合醒脑静治疗能够改善高血压脑出血患者的神经功能,调节炎症因子和神经递质的合成。

Objective：To study the effects of minimally invasive evacuation of hematoma combined with Xingnaojing therapy on neurological function damage and cytokine level in patients with hypertensive cerebral hemorrhage.Methods：A total of 80 patients with hypertensive cerebral hemorrhage treated in our hospital between June 2010 and September 2015 were selected as the research subjects,the treatment methods and test results were reviewed,and then they were divided into the control group（n=45）who accepted minimally invasive evacuation of hematoma alone and the observation group（n=35）who accepted minimally invasive evacuation of hematoma combined with Xingnaojing therapy.Before and after treatment,cerebral blood flow detector was used to detect cerebral blood flow parameters;ELISA method was used to detect serum levels of neurological function indexes and inflammatory cytokines;high performance liquid chromatograph was used to detect serum neurotransmitter levels.Results：Before treatment,the differences in cerebral blood flow parameters,neurological function indexes,inflammatory cytokines and neurotransmitters were not statistically significant between two groups of patients（P〈0.05）.After treatment,cerebral blood flow parameters Q and V levels of observation group were higher than those of control group while R level was lower than that of control group（P〈0.05）;serum NSE,NPY,IL-1β,IL-4,IL-6,TNF-α,Glu and Asp contents of observation group were lower than those of control group while BDNF and Gly contents were higher than those of control group（P〈0.05）.Conclusion：Minimally invasive evacuation of hematoma combined with Xingnaojing therapy can improve the neurological function and regulate the synthesis of inflammatory cytokines and neurotransmitters in patients with hypertension cerebral hemorrhage.