齐拉西酮联合无抽搐电休克治疗精神分裂症的血清指标及电生理特征评价

Evaluation of serum indexes and electrophysiological characteristics after ziprasidone combined with modified electroconvulsive therapy for schizophrenia

目的:研究齐拉西酮联合无抽搐电休克治疗(MECT)对精神分裂症的血清指标及电生理特征的影响。方法:选择在我院就诊的44例精神分裂症患者并随机分为MECT组和对照组,MECT组接受齐拉西酮联合MECT治疗,对照组接受齐拉西酮治疗。治疗前和治疗后1、2、3月时,测定血清中神经细胞因子含量、炎性因子含量以及神经电生理参数。结果:治疗后1、2、3月时,两组血清中BDNF、GDNF、NGF的含量均显著高于治疗前,IL-1β、IL-6、IL-17、TNF-α的含量均显著低于治疗前,P300、N2-P3的潜伏期均显著短于治疗前,P300、N2-P3的波幅均显著高于治疗前;MECT组血清中BDNF、GDNF、NGF的含量均显著高于对照组,IL-1β、IL-6、IL-17、TNF-α的含量均显著低于对照组,P300、N2-P3的潜伏期均显著短于对照组,P300、N2-P3的波幅均显著高于对照组。结论:齐拉西酮联合无抽搐电休克治疗能够改善神经元功能、减轻神经元损伤并调节神经电生理功能。

Objective：To study the effects of ziprasidone combined with modified electroconvulsive therapy（MECT）on serum indexes and electrophysiological characteristics of schizophrenia.Methods：A total of 44 patients with schizophrenia treated in our hospital between May 2014 and July 2016 were selected and randomly divided into MECT group and control group,MECT group received ziprasidone combined with MECT therapy and control group received ziprasidone therapy.Before treatment as well as 1 month,2 months and 3 months after treatment,serum nerve cytokine levels and inflammatory factor levels as well as nerve electrophysiology parameters were detected.Results：1 month,2 months and 3 months after treatment,serum BDNF,GDNF and NGF levels of both groups were significantly higher than those before treatment,IL-1β,IL-6,IL-17 and TNF-αlevels were significantly lower than those before treatment,P300 and N2-P3 latency were significantly shorter than those before treatment,and P300 and N2-P3 amplitude were significantly higher than those before treatment;serum BDNF,GDNF and NGF levels of MECT group were significantly higher than those of control group,IL-1β,IL-6,IL-17 and TNF-αlevels were significantly lower than those of control group,P300 and N2-P3 latency were significantly shorter than those of control group,and P300 and N2-P3 amplitude were significantly higher than those of control group.Conclusion：Ziprasidone combined with modified electroconvulsive therapy can improve neuron function,reduce neuron damage and adjust nerve electrophysiology function.