前列腺癌骨转移相关信号通路的研究进展

Research progress in bone metastasis associated signaling pathway of prostate cancer

全球前列腺癌发病率逐年升高,骨转移是前列腺癌主要的转移方式,并且与患者预后密切相关。前列腺癌骨转移相关信号通路揭示了骨转移发生的机制,可为临床治疗提供思路和指导。本文综述了与前列腺癌骨转移相关的信号通路,包括MET、VEGF、β2-肾上腺素信号通路、雄激素受体信号通路和RANKL信号通路,阐明了这些通路在骨转移发生过程中的作用及机制,并介绍了相关研究结果在临床治疗中的应用情况。

The incidence of prostate cancer increased year by year in the world.Bone is the main target of metastasis of prostate cancer, which is closely related to prognosis. The mechanism of bone metastasis is revealed by some signaling pathways and provides ideas and guidance for clinical treatment. This review summarizes the signaling pathways associated with bone metastasis in prostate cancer, including MET and VEGF signaling pathway, beta 2-adrenergic signaling pathway, androgen receptor signaling pathway and RANKL signaling pathway.In this review,the role and mechanism of these pathways in bone metastases are elucidated and the application of related research results in clinical treatment are also introduced.