常压敞开式质谱离子源发展趋势

Trends in Ambient Ion Source Mass Spectrometry

近年来常压敞开式离子源凭借快速、原位、实时离子化样品等优势,被广泛应用于样品快速筛查、真伪鉴定、质谱成像等领域,已成为当今离子源的研究热点,受到了学术界及仪器制造、化学和生物分析等相关产业界的广泛关注。目前,该类离子源朝着克服基体效应、提高样品表面定位能力及增加离子传输距离等方向发展。本文主要介绍了可以很好解决上述问题并具有代表性的三种常压敞开式离子源:电喷雾萃取离子源(EESI)、介质阻挡放电离子源(DBDI)及空气动力辅助离子源(AFAI),重点涉及原理以及在此基础上所做的设计改进和应用进展。

Ambient ion source has been widely used in rapid screening of samples,sample identification,mass-spectrometry imaging and other fields in recent years,because of its outstanding features including rapid,in situ,real-time ionization of sample.Consequently,it has attracted lots of attentions,especially in the areas of academia,instrument manufacturing,chemical and biological analysis,etc.Nowadays ambient ion source tends to strengthen the abilities of overcoming the matrix effects,improving positioning capacity of sample surface and increasing the ion transmission distances.This paper mainly introduces three kinds of representative ambient ion sources,i.e.electrospray extraction ionization（EESI）,dielectric barrier discharge ion source（DBDI）and air flow assisted ionization（AFAI）,emphasizing their principles,design improvements and application progresses.