超敏C反应蛋白、尿酸、脑钠肽与冠心病的相关性

Correlation among concentrations of high sensitive C reactive protein,uric acid,brain natriuretic peptide and coronary heart disease

目的:探讨超敏C反应蛋白(hsCRP)、尿酸(UA)、脑钠肽(BNP)与冠心病(CHD)之间的相关性。方法:选择我院心血管内科收治的冠心病患者120例(CHD组),分为单支病变组(51例)和多支病变组(69例),另于我院体检中心随机选择同期40例健康体检者作为健康对照组,检测各组血清hsCRP、BNP、UA浓度,并进行比较。结果:与健康对照组比较,CHD组血清hsCRP[(3.95±2.24)mg/L比(19.78±5.15)mg/L]、BNP[(70.57±19.47)pg/ml比(196.17±54.84)pg/ml]、UA[(184.51±79.47)μmol/L比(407.17±96.84)μmol/L]浓度明显升高,且多支病变组hsCRP、BNP、UA浓度明显高于单支病变组(P<0.05或<0.01);Spearman等级相关分析显示,CHD患者血清UA浓度与hsCRP、BNP浓度呈显著正相关(r=0.551、0.398,P均<0.05),Gensini积分与血清hsCRP、BNP、UA浓度呈显著正相关(r=0.478、0.552、0.741,P均<0.05),Sullivan积分与血清hsCRP、BNP、UA浓度呈显著正相关(r=0.503、0.674、0.892,P<0.05或<0.01)。结论:血清hsCRP、BNP、UA浓度与CHD的发生及发展紧密相关,三者均可作为CHD的筛查指标且联合检测效果可能更好。

Objective： To explore correlation among concentrations of high sensitive C reactive protein （hsCRP）, uric acid （UA）, brain natriuretie peptide （BNP） and coronary heart disease （CHD）. Methods： A total of 120 CHD patients treated in our department were enrolled as CHD group, and they were divided into single vessel coronary disease group （single-vessel group, n = 51） and multi-vessel coronary disease group （multi-vessel group, n = 69）. Meanwhile, another 40 healthy subjects were randomly selected from our physical examination center as healthy control group. Serum concentrations of hsCRP, BNP and UA were measured in all groups, and compared with pairwise comparisons. Results： Compared with healthy control group, there were significant rise in serum concentrations of hsCRP [ （3. 95 ± 2. 24） mg/L vs. （19.78 ± 5. 15） mg/L], BNP [ （70. 57 ± 19.47） pg/ml vs. （196. 17 ± 54. 84） pg/ ml], UA [ （184. 51 ± 79.47） μmol/L vs. （407. 17± 96.84） μmol/L] in CHD group, and those of multi-vessel group were significantly higher than those of single-vessel group, P〈0.05 or 〈0. 01; Spearman rank correlation analysis indicated that serum UA concentration was significant positively correlated with hsCRP and BNP concentrations （r = 0. 551, 0. 398, P〈0.05 both）, Gensini score was significant positively correlated with serum concentrations of hsCRP, BNP, UA （r = 0. 478, 0. 552, 0. 741, P〈0.05 all）, Sullivan score was significant positively correlated with serum concentrations of hsCRP, BNP, UA （ r = 0. 503, 0. 674, 0. 892, P〈0.05 or 〈0.01） in CHD patients. Conclusinn.. Serum concentrations of hsCRP, BNP, UA are closely related to occurrence and development of CHD. These three indexes can be used as screening indexes for CHD, and the effect of combined detection may be better.