生长抑素、神经元特异性烯醇化酶与早期血管性痴呆的关系

Relationship among somatostatin,neuron-specific enolase and early vascular dementia

目的:探讨生长抑素(SS)、神经元特异性烯醇化酶(NSE)与早期血管性痴呆的关系。方法:选择于我院接受治疗的40例早期血管性痴呆患者(血管性痴呆组),另选择40例同一时期住院治疗的脑梗死患者(脑梗死组)。比较两组患者不同时期血浆NSE及SS水平。结果:与脑梗死组脑梗死时,脑梗死后1月、3月时比较,血管性痴呆组血浆NSE水平[(22.08±7.05)ng/ml比(26.39±6.80)ng/ml、(23.92±4.25)ng/ml比(28.12±4.06)ng/ml、(25.55±4.72)ng/ml比(30.10±4.33)ng/ml]均明显升高,SS水平[(1084.50±133.00)ng/ml比(748.30±129.10)ng/ml、(836.40±160.20)ng/ml比(624.25±140.50)ng/ml、(690.25±146.30)ng/ml比(432.70±151.00)ng/ml]明显降低(P<0.05或<0.01)。且随着脑梗死时间的推移,两组血浆NSE水平均逐渐升高,SS水平逐渐降低(P<0.05或<0.01)。结论:早期动态检测脑梗死患者生长抑素和神经元特异性烯醇化酶水平,有助于血管性痴呆的早期诊断和治疗。

Objective： To explore the relationship among somatostatin （SS）, neuron-specific enolase （NSE） and early vascular dementia. Methods： A total of 40 patients with early vascular dementia treated in our hospital were selected as vascular dementia group, another 40 inpatients with cerebral infarction （CI） treated during the same period were enrolled as CI group. Plasma NSE and SS levels were compared between two groups during different periods. Results： Compared with CI group at onset, one month and three months after CI, there was significant rise in plasma NSE level [ （22.08± 7.05） ng/ml vs. （26.39 ± 6.80） ng/ml, （23.92 ± 4. 25） ng/ml vs. （28.12 ± 4.06） ng/ml, （25.55 ± 4.72） ng/ml vs. （30.10 ± 4.33） ng/ml], and significant reduction in plasma SS level [ （1084. 50 ± 133.00） ng/ml vs. （748.30 ± 129.10） ng/ml, （836.40 ± 160.20） ng/ml vs. （624. 25 ± 140.50） ng/ml, （690.25 ± 146.30） ng/ml vs. （432.70 ± 151.00） ng/ml] in vascular dementia group, P〈0.05 or G0.01. Plasma NSE level gradually rose and SS level gradually reduced along with the time went by （P〈0.05 or 〈0.01）. Conclusion, Early dynamic detection of somatostatin and neuron-specific enolase levels in patients with cerebral infarction may help to early diagnosing and treatment of vascular dementia.