吸烟、Hcy、CRP与青年人冠心病发病的关系

Relationship among smoking,levels of homocysteine,C reactive protein and coronary heart disease onset in young people

目的:分析吸烟、同型半胱氨酸(Hcy)、半胱氨酸蛋白酶抑制剂C(Cys C)、C反应蛋白(CRP)与年轻人冠心病(CHD)发病的关系。方法:选择我院收治因胸痛行选择性冠状动脉造影患者152例为研究对象,年龄均在45岁以下,依照检查结果分为CHD组(100例)和非CHD(52例),分析各组临床资料,并采用Logistic多元回归分析年轻CHD的独立危险因素。结果:与非冠心病组比较,冠心病组患者男性(30.8%比65.0%)、吸烟(46.1%比68.0%)、高血压(34.6%比51.0%)比例显著升高(P<0.05或<0.01),CysC[(0.85±0.16)mg/L比(1.34±0.28)mg/L]、CRP[(1.26±0.85)mg/L比(6.93±0.85)mg/L]、Hcy[(7.16±1.16)μmol/L比(20.85±2.16)μmol/L]、水平显著升高(P均<0.01);多元Logistic回归分析显示,男性,高血压,吸烟,Hcy和CRP是青年人发生冠心病的危险因素(OR=1.34~3.42,P<0.05或<0.01)。结论:男性,吸烟,同型半胱氨酸、Cys C及C反应蛋白是青年人发生冠心病的危险因素,应消除或降低这些危险因素的危险性。

Objective： To analyze the relationship among smoking, levels of homocysteine （Hcy）, cystatin C （CysC）, C reactive protein （CRP） and coronary heart disease （CHD） onset in young people. Methods： A total of 152 patients, who received selective coronary angiography because of chest pain in our hospital, were enrolled, and all subjects were 〈45 years old. According to examination results, they were divided into CHD group （n = 100） and non- CHD group （n ： 52） . Clinical data were analyzed in both groups, and Logistic multi - factor regression analysis was used to analyze independent risk factors for CHD in young people. Results： Compared with non-CHD group, there were significant rise in percentages of men （30.8% vs. 65.0%）, smoking （46.1% vs. 68. 0%） and hypertension （34.6% vs. 51.0%）, levels ofCysC [ （0.85±0.16） mg/Lvs. （1.34±0.28） mg/L], CRP[ （1.26±0.85） mg/L vs. （6.93±0.85） mg/L] andHcy [ （7.16±1.16） mol/Lvs. （20.85±2.16） mol/L], P〈0.05or 〈0.01; multi - factor Logistic regression analysis indicated that male, hypertension, smoking, Hcy, CysC and CRP were risk factors for CHD in young people （OR= 1.34-3.42, P〈0.05 or 〈0.01）. Conclusion： Male, smoking, total cholesterol, homocysteine, Cys C and C reactive protein are risk factors for CHD in young people. Therefore, these risk factors should be eliminated, or its risk should be reduced.