冠心病患者血浆氧化低密度脂蛋白与血管内皮损伤程度的相关性

Correlation between plasma oxidized low density lipoprotein and vascular endothelial injury degree in patients with coronary heart disease

目的:探讨冠心病患者血浆氧化低密度脂蛋白(ox-LDL)与内皮损伤程度的相关性。方法:选择80例冠心病患者(CHD组),21例正常人群(健康对照组),检测各组血浆ox-LDL、循环内皮细胞计数(CEC)、一氧化氮(NO)水平,并分析其相关性。结果:与健康对照组比较,CHD组患者ox-LDL水平[(350±173)μg/L比(687±169)μg/L]、CEC[(2.5±0.5)×10~6个/L比(9.0±1.7)×10~6个/L]明显增加,NO[(77.4±21.1)μmol/L比(52.3±16.6)μmol/L]水平明显降低(P<0.05或<0.01)。Spearman相关分析显示,ox-LDL与CEC呈明显正相关(r=0.793,P=0.019),ox-LDL,CEC与NO呈明显负相关(r=-0.782,-0.952,P=0.013,0.021)。结论:冠心病患者血浆氧化低密度脂蛋白与循环内皮细胞计数(血管内皮损伤程度)呈明显正相关,因此对于冠心病患者应重视抗炎和保护血管内皮细胞.

Objective： To explore correlation between plasma oxidized low density lipoprotein （ox-LDL） and endothelial injury degree in patients with coronary heart disease （CHD）. Methods： A total of 80 CHD patients were enrolled as CHD group, and 21 healthy subjects were selected as healthy control group. Plasma ox-LDL, circulatory endothelial cell count （CEC）, nitric oxide （NO） levels were measured and compared between two groups, and their correlation was analyzed. Results： Compared with healthy control group, there were significant rise in plasma ox-LDL level[（350 ± 173） μg/L vs. （687 ± 169） μg/L] and CEC [ （2.5 ± 0.5） ×10^6个/L vs. （9.0 ± 1.7） ×10^6个/L], and significant reduction in NO level [ （77.4 ± 21.1） μmol/L vs. （52.3 ± 16.6） μmol/L] in CHD group, P〈0.05 or 0.01. Spearman correlation analysis indicated that ox-LDL was significant positively correlated with CEC （ r = 0. 793, P = 0. 019 ）, and ox-LDL, CEC were significant negatively correlated with NO level （ r = - 0. 782, - 0. 952, P = 0. 013, 0. 021）. Conclusion.. There are significant positively correlation between ox-LDL and circulatory endothelial cell count （Vascular endothelial injury degree） in CHD patients, therefore, its treatment should focus on anti-inflammatory and endothelial cell function protection .