摘要
目的:探讨冠心病患者血浆氧化低密度脂蛋白(ox-LDL)与内皮损伤程度的相关性。方法:选择80例冠心病患者(CHD组),21例正常人群(健康对照组),检测各组血浆ox-LDL、循环内皮细胞计数(CEC)、一氧化氮(NO)水平,并分析其相关性。结果:与健康对照组比较,CHD组患者ox-LDL水平[(350±173)μg/L比(687±169)μg/L]、CEC[(2.5±0.5)×10~6个/L比(9.0±1.7)×10~6个/L]明显增加,NO[(77.4±21.1)μmol/L比(52.3±16.6)μmol/L]水平明显降低(P<0.05或<0.01)。Spearman相关分析显示,ox-LDL与CEC呈明显正相关(r=0.793,P=0.019),ox-LDL,CEC与NO呈明显负相关(r=-0.782,-0.952,P=0.013,0.021)。结论:冠心病患者血浆氧化低密度脂蛋白与循环内皮细胞计数(血管内皮损伤程度)呈明显正相关,因此对于冠心病患者应重视抗炎和保护血管内皮细胞.
Objective: To explore correlation between plasma oxidized low density lipoprotein (ox-LDL) and endothelial injury degree in patients with coronary heart disease (CHD). Methods: A total of 80 CHD patients were enrolled as CHD group, and 21 healthy subjects were selected as healthy control group. Plasma ox-LDL, circulatory endothelial cell count (CEC), nitric oxide (NO) levels were measured and compared between two groups, and their correlation was analyzed. Results: Compared with healthy control group, there were significant rise in plasma ox-LDL level[(350 ± 173) μg/L vs. (687 ± 169) μg/L] and CEC [ (2.5 ± 0.5) ×10^6个/L vs. (9.0 ± 1.7) ×10^6个/L], and significant reduction in NO level [ (77.4 ± 21.1) μmol/L vs. (52.3 ± 16.6) μmol/L] in CHD group, P〈0.05 or 0.01. Spearman correlation analysis indicated that ox-LDL was significant positively correlated with CEC ( r = 0. 793, P = 0. 019 ), and ox-LDL, CEC were significant negatively correlated with NO level ( r = - 0. 782, - 0. 952, P = 0. 013, 0. 021). Conclusion.. There are significant positively correlation between ox-LDL and circulatory endothelial cell count (Vascular endothelial injury degree) in CHD patients, therefore, its treatment should focus on anti-inflammatory and endothelial cell function protection .
出处
《心血管康复医学杂志》
CAS
2017年第2期167-170,共4页
Chinese Journal of Cardiovascular Rehabilitation Medicine
关键词
冠心病
内皮
血管
脂蛋白类
Coronary disease
Endothelium, vascular
Lipoproteins, LDL