血脂水平与体外受精周期胚胎质量的相关性研究

Study on the correlation between serum lipid level and anti-Müllerian hormone with embryo quality in vitro fertilization cycle

目的探讨血脂水平与体外受精周期胚胎质量的相关性研究。方法收集2015年10月至2016年6月在该院生殖中心接受体外受精-胚胎移植技术(IVF-ET)治疗的不孕夫妇603对。所有受试者均接受长方案超排卵,检测不同时期的血脂水平,评判胚胎质量。结果三酰甘油(TG)、总胆固醇(TC)和体质量指数(BMI)与受精率、2个卵细胞内原核(2PN)受精率、卵裂率和优胚率均呈负相关关系(P<0.05),低密度脂蛋白(LDL)、非高密度脂蛋白(NHDL)和脂蛋白(a)[Lp(a)]与受精率、2PN受精率、卵裂率和优胚率均呈负相关关系趋势,但差异无统计学意义(P>0.05),高密度脂蛋白(HDL)与受精率、2PN受精率、卵裂率和优胚率呈正相关关系趋势,但差异无统计学意义(P>0.05)。结论血脂水平与胚胎质量呈线性相关性,可见检测血脂可用于评估胚胎质量,为IVF-ET治疗过程控制提供判定依据。

Objective To study the relationship between serum lipid level with embryo quality in vitro fertilization cycle.Methods A total of 603 pairs of infertile couples who were treated with in vitro fertilization and embryo transfer technique（IVF-ET）in our hospital from October 2015 to June 2016 were collected.All subjects underwent long-term ovarian hyperstimulation,blood lipid and the embryo quality were measured and evaluated.Results Triglyceride（TG）,total cholesterol（TC）and body mass index（BMI）were significantly negatively correlated with fertilization rate,2PN fertilization rate,cleavage rate and embryo rate（P〈0.05）.Density lipoprotein（LDL）and non-high density lipoprotein（NHDL）and lipoprotein（a）[Lp（a）]were negatively correlated with fertilization rate,2PN fertilization rate,high density lipoprotein.The cholesterol（HDL）were positively correlated with fertilization rate,2PN fertilization rate,cleavage rate and embryo rate（P〉0.05）.Conclusion There is a linear correlation between blood lipid level and AMI and embryo quality.Serum lipids and AMI can be used to evaluate the quality of embryo and provide suggestion for the quality control of IVF-ET.