尿β2微球蛋白及D-二聚体与妊娠期高血压肾脏损伤的相关性研究

The relationship research between β2-microglobulin and D-Dimer concentration and kidney injury in pregnancy-induced hypertension patients

目的对尿β2微球蛋白及D-二聚体与妊娠期高血压肾脏损伤的相关性进行研究,为临床诊断和治疗提供参考。方法以湖北省十堰市郧西县人民医2010年11月至2015年11月诊治的妊娠期高血压早期肾脏损伤患者120例作为研究对象(观察组),分析患者尿素氮、血肌酐、尿酸水平,并检测患者尿β2微球蛋白及D-二聚体水平的变化;以该院同期健康体检者100例为对照组,正常妊娠期妇女120例为正常妊娠组。结果与对照组和正常妊娠组相比,观察组患者尿素氮、血肌酐、尿酸、微量蛋白尿、β2微球蛋白、血微球蛋白及D-二聚体水平均明显升高,且差异均具有统计学意义(P<0.05);观察组患者体内载蛋白(NGAL),碱蛋白(NLRP3),还原型辅酶Ⅱ(NADPH)氧化酶亚基P22亚基、P47亚基、P67亚基、gp91亚基,转化生长因子β(TGFβ),Smad2及Smad3水平均明显升高,且差异均具有统计学意义(P<0.05)。结论尿β2微球蛋白及D-二聚体与妊娠期高血压肾脏损伤有明显的相关性,可作为临床诊断的标志物。

Objective To explore the relationship betweenβ2-microglobulin and D-Dimer concentration in the pregnancy-induced hypertension patients with kidney injury.Methods The 120 cases of kidney injury pregnancy-induced hypertension patients were enrolled in our hospital from Nov 2010 to Nov 2015（served as observation group）.The levels of BUN,Scr,UA,β2-microglobulin and D-Dimer were detected.The 100 cases of healthy subjects and 120 cases of normal pregnancy women were taken as controls,respectively.Results Compared with healthy control and normal pregnancy women,the levels of BUN,Scr,UA were increased significantly in the observation group（P〈0.05）.The results also showed that the expression of NGAL,NLRP3,NADPH oxidase subunits,TGFβ,Smad2,Smad3,β2-microglobulin and D-Dimer were sharply increased as compared with the other two group（P〈0.05）.Conclusion β2-microglobulin and D-Dimer are significantly related with pregnancy-induced hypertension patients with kidney injury and they would be taken as clinical indicators for the diagnosis of this disease.