肥胖症非酒精性脂肪肝病的发病机制研究进展被引量：10

下载PDF

导出

摘要非酒精性脂肪肝病（nonalcoholic fatty liverdisease,NAFLD）包括单纯性非酒精性脂肪肝、非酒精性脂肪肝炎、肝硬化等-组慢性非酒精所致脂肪肝病,未来可能是肝病患者需要肝脏移植的首位病因[1].世界范围内,NAFLD的流行程度与代谢综合征尤其是肥胖症的发病率成正相关.针对此二种疾病的发病机制,非酒精性脂肪肝病的研究主要涉及以下方面：“二次打击”学说、胆汁酸受体介导的能量消耗及糖脂代谢理论、炎症因子释放并介导肝纤维化的形成机制、胃肠微生物群体变化和肥胖相关基因的多态性等;肥胖症发病机制的研究主要倾向于遗传学（包括肥胖基因及节俭基因假说）、胃肠微生物群体及脂质代谢方面.

作者刘瑞侠黄有烨胡红琳

机构地区安徽医科大学第一附属医院内分泌科

出处《安徽医学》 2017年第4期512-516,共5页 Anhui Medical Journal

基金安徽高校省级自然科学研究项目(项目编号:KJ2013Z126) 安徽中医学院中医药管理局重点学科-中医内分泌学科开放基金(项目编号:2011nfmxk004)

关键词非酒精性脂肪肝病肥胖症发病机制

分类号 R575 [医药卫生—消化系统] R589.2 [医药卫生—内分泌]

引文网络
相关文献

参考文献2

1Weina Wang Wei Zhou Baolong Wang Haiyan Zhu Li Ye Meiqing Feng.Antioxidant effect of apolipoprotein A-I on high-fat diet-induced non-alcoholic fatty liver disease in rabbits[J].Acta Biochimica et Biophysica Sinica,2013,45(2):95-103. 被引量：5
2Tim CMA Schreuder,Bart J Verwer,Carin MJ van Nieuwkerk,Chris JJ Mulder.Nonalcoholic fatty liver disease: An overview of current insights in pathogenesis, diagnosis and treatment[J].World Journal of Gastroenterology,2008,14(16):2474-2486. 被引量：36

二级参考文献164

1[1]World Health Organization.Obesity and Overweight.2003.Available from:URL:http://www.who.int/dietphysicalactivity/media/en/gsfs_obesity.pdf
2[2]James PT,Leach R,Kalamara E,Shayeghi M.The worldwide obesity epidemic.Obes Res 2001; 9 Suppl 4:228S-233S
3[3]Ogden CL,Yanovski SZ,Carroll MD,Flegal KM.The epidemiology of obesity.Gastroenterology 2007; 132:2087-2102
4[4]Alberti KG,Zimmet P,Shaw J.Metabolic syndrome-a new world-wide definition.A Consensus Statement from the International Diabetes Federation.Diabet ivied 2006; 23:469-480
5[5]Day C.Metabolic syndrome,or What you will:definitions and epidemiology.Diab Vasc Dis Res 2007; 4:32-38
6[6]Johnson LW,Weinstock RS.The metabolic syndrome:concepts and controversy.Mayo Clin Proc 2006; 81:1615-1620
7[7]Bergman RN,Kim SP,Catalano KJ,Hsu IR,Chiu JD,Kabir M,Hucking K,Ader M.Why visceral fat is bad:mechanisms of the metabolic syndrome.Obesity (Silver Spring) 2006; 14 Suppl 1:16S-19S
8[8]Laclaustra M,Corella D,Ordovas JM.Metabolic syndrome pathophysiology:the role of adipose tissue.Nutr Metab Cardiovase Dis 2007; 17:125-139
9[9]Chavez-Tapia NC,Mendez-Sanchez N,Uribe M.The metabolic syndrome as a predictor of nonalcoholic fatty liver disease.Ann Intern Med 2006; 144:379; author reply 380
10[10]Hamaguchi M,Kojima T,Takeda N,Nakagawa T,Taniguchi H,Fujii K,Omatsu T,Nakajima T,Sarui H,Shimazaki M,Kato T,Okuda J,Ida K.The metabolic syndrome as a predictor of nonalcoholic fatty liver disease.Ann Intern Med 2005; 143:722-728