慢性精神分裂症患者血清IL-2、IL-4和IL-10水平及与精神症状的相关性

Changes in serum IL-2,IL-4 and IL-10 levels and its correlation with psychiatric symptoms in chronic schizophrenia patients

目的探讨慢性精神分裂症患者血清白细胞介素2(IL-2)、白细胞介素4(IL-4)和白细胞介素10(IL-10)的水平变化及其与精神症状的相关性。方法于2012年12月-2013年10月在广州医科大学附属脑科医院采用抽签法选取符合《国际疾病分类(第10版)》(ICD-10)诊断标准的40例慢性精神分裂症住院患者为患者组,同期通过广告招募64例健康对照者为对照组。采用酶联免疫吸附试验(ELISA)检测两组血清IL-2、IL-4和IL-10水平,采用阳性和阴性症状量表(PANSS)评估患者组的精神症状。结果患者组血清IL-2水平高于对照组[(25.85±6.06)pg/m L vs.(12.63±1.90)pg/m L],差异有统计学意义(P<0.05);两组血清IL-4水平[(7.36±1.54)pg/m L vs.(8.76±3.13)pg/m L]和IL-10水平[(4.29±0.87)pg/m L vs.(3.76±1.17)pg/m L]比较,差异均无统计学意义(P均>0.05);患者组血清IL-2、IL-4和IL-10水平与病程、住院时长、抗精神病药治疗剂量及PANSS评分均无线性相关(P均>0.05)。结论慢性精神分裂症患者的血清IL-2水平高于健康对照者,IL-4和IL-10水平与对照者比较未见差异;IL-2、IL-4和IL-10水平与患者的精神症状未见线性相关性。

Objective To assess serum concentrations of Interleukin-2 （IL-2）,I L-4 and IL-10in chronic schizophrenia patients and to analyze the correlations between the serum cytokine levels with the patients^ psychiatric symptoms.Methods Random sampling method was applied to choose 40chronic schizophrenia inpatients diagnosed according to International Classification of Diseases-tenth edition（ICD -10） diagnostic criteria at the Affiliated Brain Hospital of Guangzhou Medical University from December 2012 to October 2013 as patient group.64 healthy control subjects were recruited through advertisements at the Affiliated Brain Hospital of Guangzhou Medical University during the same period as control group.Enzyme-linked Immune Sorbent Assay （ELISA） was applied to detect serum IL-2,IL-4 and IL-10concentrations in control group and patient group.The Positive and Negative Syndrome Scale （PANSS） was applied to estimate the psychotic symptoms of schizophrenia patients.Results Serum IL-2 concentrations were significantly higher in schizophrenia patients （25.85±6.06） pg/mL than controls （ 12.63± 1.90） pg/mL （ P〈0.05 ）,while IL-4（7.36± 1.54） pg/mL and IL-10（4.29± 0.87） pg/mL concentrations in patients were not significantly different from IL-4 （8.76±3.13） pg/mL and IL -10（3.76±1.17） pg/mL concentrations in controls （ P〉0.05 ） .Serum IL-2,IL-4 and IL-10concentrations showed no significant associations with duration of illness,duration of admission,antipsychotic dose,PANSS scores in patients （P〉0.05）.Conclusion IL-2 levels are increased in chronic schizophrenia patients,while IL-4 and IL-10levels in chronic schizophrenia patients are not significantly different from those in controls.IL-2,IL-4 and IL-1 0levels are not associated with psychiatric symptoms.