Galectin-3、P27蛋白在癌前病变患者中的表达及预后价值研究

Expression and prognostic value of Galectin-3 and P27 proteins in precancerous Lesions

目的:观察Galectin-3、P27蛋白在癌前病变患者中的表达及预后价值。方法:2015-01~2016-07我院收治癌前病变患者90例为观察组,取同期入院健康体检者90例为对照组。采用免疫组化二步法检测2组Galectin-3、P27蛋白水平,分析其在癌前病变患者中的表达及预后情况。结果:观察组Galectin-3蛋白阳性率高于对照组(P<0.05),P27蛋白阳性率低于对照组(P<0.05);对照组Galectin-3蛋白免疫组化染色下细胞阳性表达相对较少,而P27蛋白阳性表达相对较多;观察组Galectin-3蛋白免疫组化染色下细胞阳性表达相对较多,而P27蛋白阳性表达相对较少。结论:癌前病变患者检测Galectin-3、P27蛋白水平效果理想,Galectin-3蛋白在癌前病变中可能发挥促进作用,而P27蛋白水平低表达可能与肿瘤的发生、发展有关,均需要进一步研究和验证。

Objective： To investigate the expression and prognostic value of Galectin-3 and P27 protein in precancerous lesions. Methods： Ninety patients with precancerous lesions admitted in the hospital from January 2015 to July 2016 were enrolled in this study. Ninety patients with normal control were enrolled. The expressions of Galectin-3 and P27 protein in the precancerous lesions were analyzed by immunohistochemistry and the expression of Galeetin-3 and P27 protein in the patients with precancerous lesions were analyzed. Results： The positive rate of Galectin-3 was higher than that of the control group （P 〈0.05）.The positive rate of P27 protein in the observation group was lower than that in the control group （P〈0.05） ;Galectin-3 immunohistochemical staining The positive expression of P27 protein was relatively high,but the positive expression of P27 protein was relatively high.The positive expression of Galectin-3 protein was relatively lower and the expression of P27 protein was lower.Conclusion：Galectin-3 and P27 protein levels are ideal for the detection of precancerous lesion.Galectin-3 may play a role in precancerous lesions.The low expression of P27 may be related to tumorigenesis and progression,which need further study and validation.