Hedgehog信号通路促进血吸虫病肝纤维化的新机制及其药物治疗

Newly identified ways in which the hedgehog signaling pathway plays a role in schistosomiasis-induced hepatic fibrosis and corresponding drug therapies

慢性血吸虫病对机体造成的病理损害以血吸虫病肝纤维化最为突出,然而目前对血吸虫病造成肝纤维化的发病机制仍缺乏足够的认识,也缺乏有效的抗肝纤维化药物。本文主要阐述了Hedgehog信号通路参与血吸虫病肝纤维化发病机制的最新研究进展,并探讨了相应的药物干预手段。Hedgehog信号通路抑制剂可能会是血吸虫病肝纤维化患者的福音。

Schistosomiasis invariably results in hepatic fibrosis, but the exact mechanisms that underlie these processes are unclear, and there is also a lack of effective medications. This article reviews the newly identified ways in which the hedgehog signaling pathway plays a role in schistosomiasis-induced hepatic fibrosis. This article also examines potential drugs to block that pathway. Hedgehog pathway inhibitors may benefit patients with hepatic fibrosis due to schistoso miasis.