Toll样受体4在结核分枝杆菌感染中的作用和研究进展

Advances in the study of the role of Toll-like receptor 4 in tuberculosis

结核病是全球范围内传播最广的感染性疾病,其防治形势十分严峻。MTB与宿主细胞之间的相互作用十分复杂,免疫因素在TB的发生和发展过程中起重要作用,Toll样受体4是重要的模式识别受体,单核巨噬细胞、树突细胞、肺泡Ⅱ型上皮细胞均表达TLR4,在抵抗结核分枝杆菌感染中发挥重要作用。本文对Toll样受体4在结核分枝杆菌感染中的作用和研究进展进行综述。

Tuberculosis （TB） is the most widespread infectious disease in the world and its prevention and control isquite daunting. Interaction between Mycobacteriurn tuberculosis and host cells is complex. Immune factors play an impor tant role in the incidence and development of TB. Toll-like receptor 4 is an important pattern recognition receptor ex pressed on the surface of macrophages, dendritic cells, and alveolar epithelial type II cells, and Toll-like receptor 4 plays a crucial role in resistant TB. This paper reviews the role of the Toll-like receptor 4 in TB and advances in the study of TB.